en Radiotherapy Radiotherapy مقاله مروری Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Times New Roman;"><span style="font-size:14px;">Numerous studies have shown that combining hyperthermia (HT) with other breast cancer treatment strategies can yield beneficial outcomes. Research indicates that HT may enhance tumor reduction, improve local tumor control, and potentially contribute to increased survival rates. Nonetheless, further investigations are essential to fully elucidate its therapeutic advantages and to establish the most effective protocols for its integration into breast cancer care. In response to hyper thermic stress, the body activates protective mechanisms, notably the upregulation of heat shock proteins (HSPs). These proteins help mitigate cellular damage and dysfunction by enabling cells to better withstand elevated temperatures. As such, understanding the behavior of HSPs under hyper thermic conditions is a vital area of research for exploring how cells cope with thermal stress and for identifying novel therapeutic targets. HSPs represent a conserved group of proteins present in both prokaryotic and eukaryotic cells. They are essential for maintaining protein homeostasis (proteostasis) and safeguarding cells from various stressors. Classified by molecular weight, HSPs act as molecular chaperones, facilitating the folding of newly synthesized polypeptides, refolding misfolded proteins, assembling multi-protein complexes, and degrading damaged proteins. In addition to their chaperone activity, HSPs play key roles in<b> </b>cellular signaling pathways, regulation of the cell cycle, and the initiation of apoptosis.<b> </b></span></span></span></div> Hyperthermia, Breast cancer, Clinical trials, Nanoparticles, Anticancer drugs 138 149 http://ijbc.ir/browse.php?a_code=A-10-2392-1&slc_lang=en&sid=1 Alaa Sameer Neamah 100319475328460013329 100319475328460013329 No College of Nursing, University of Dhi Qar, Dhi Qar, Irag Nima Khavaninzadeh 100319475328460013330 100319475328460013330 No Department of Industrial and Environmental Biotechnology, National Institute for Genetic Engineering and Biotechnology NIGEB, Tehran, Iran. Ali Bonakdar 100319475328460013331 100319475328460013331 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Zeynab Haj Mohammadi 100319475328460013332 100319475328460013332 No Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Simzar Hosseinzadeh s.hosseinzadeh@sbmu.ac.ir 100319475328460013333 100319475328460013333 Yes Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.