en Adults Hematology & Oncology Adults Hematology & Oncology مقاله مروری Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span new="" roman="" times="">Adoptive cellular immunotherapy has evolved into a remarkably potent precision medicine approach that has revolutionized cancer therapy, particularly for hematologic cancers, due to chimeric antigen receptor therapy, or CAR. &nbsp;The historical development, immunological concepts, CAR architecture, and manufacturing procedure that support the therapeutic potency of CAR T-cell are outlined in this paper. subsequently this study provides an overview of the history, immunological ideas, CAR architecture, and manufacturing techniques that enhance the efficacy of CAR T-cell, emphasizes significant toxicities like cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, as well as current management approaches, while highlighting the outstanding therapeutic results attained in lymphomas, B-cell acute lymphoblastic leukemia, and multiple myeloma. The paper also looks at therapeutic resistance mechanisms, obstacles to solid tumor efficacy, and new engineering solutions like logic-gated, multi-target, and armored CAR constructs. Lastly, new advances in combination therapy, earlier-line clinical applications, and &quot;off-the-shelf&quot; allogeneic CAR T-cells are being studied as potential methods to enhance accessibility, safety, durability, and broader therapeutic utility. All things considered, CAR T-cell therapy is a groundbreaking development in contemporary oncology that has the potential to fundamentally alter how cancer is treated in the future.</span></span></span></span></div> Cytokine release syndrome (CRS), Solid tumors, Blood-related cancers, Cancer immunotherapy, Chimeric antigen receptor (CAR) T-cell , Medical therapy, Allogeneic CAR T-cells 90 101 http://ijbc.ir/browse.php?a_code=A-10-2635-1&slc_lang=en&sid=1 Harsha Sri Kamma hk186909@gmail.com Yes Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur. AP, India. Mounika K No Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur. AP, India. Sambasiva Raju S No Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur. AP, India. Shainisha K No Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur. AP, India. Pranathi D No Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur. AP, India. Sai Venkat R No Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur. AP, India. Sree Charan Ekambarapu No Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576140, India. Sathish Kumar Konidala No Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan's Foundation for Science, Technology & Research, Vadlamudi, Guntur, 522213, Andhra Pradesh, India. Srinivasa Babu Puttagunta No Department of Pharmaceutics, Vignan Pharmacy College, Vadlamudi, Guntur. AP, India.