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:: Volume 5, Issue 3 (Spring 2013) ::
IJBC 2013, 5(3): 115-120 Back to browse issues page
Treatment of a Child with Refractory Acute Myeloid Leukemia with Humanized Anti-CD33 Monoclonal Antibody: A Case Report and Review of Drug Development
Samin Alavi * , Mohammad Taghi Arzanian
Abstract:   (12634 Views)
Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozogamicin has been used to induce remission in relapsed patients. Report of the case: Here, we report the first Iranian child, an 8-year-old boy, with refractory acute myeloid who was treated with gemtuzumab ozogamicin. Unfortunately, remission was not achieved and the patient died of neutropenia and septic shock. Conclusion: Gemtuzumab ozogamicin therapy in our case was not successful in achieving remission. It could be due to longstanding chemotherapy and its detrimental effects on bone marrow of the patient. Further controlled studies are necessary to learn more about efficacy and safety of this new treatment. Keywords: Childhood acute myeloid leukemia, refractory, treatment, gemtuzumab ozogamicin
Keywords: Childhood acute myeloid leukemia, refractory, treatment, gemtuzumab ozogamicin
Full-Text [PDF 527 kb]   (1561 Downloads)    
: Research | Subject: Pediatric Hematology & Oncology
Received: 2012/10/10 | Accepted: 2013/01/16 | Published: 2013/07/30
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Alavi S, Arzanian M T. Treatment of a Child with Refractory Acute Myeloid Leukemia with Humanized Anti-CD33 Monoclonal Antibody: A Case Report and Review of Drug Development. IJBC. 2013; 5 (3) :115-120
URL: http://ijbc.ir/article-1-413-en.html


Volume 5, Issue 3 (Spring 2013) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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