Shaiegan M, Yari F, Abolghasemi H, Bagheri N, Paridar M, Heidari A, et al . Allele Frequencies of HLA-A, B and DRB1 among People of Fars Ethnicity Living in Tehran. Iranian Journal of Blood and Cancer 2011; 3 (4) :55-59
URL:
http://ijbc.ir/article-1-362-en.html
Abstract: (9756 Views)
Background: Human leukocyte antigens (HLA) are polymorphic cell surface proteins. Distribution of HLA alleles
vary among different racial and ethnic populations in unrelated stem cell registries. Determination of HLA allele
frequencies in different ethnic groups is useful for population genetic analyses.
Materials and Methods: Based on data available from the Iranian Stem Cell Donor Registry, HLA-A, B, DRB1 allele
frequencies were evaluated from 244 individuals who were recruited as unrelated volunteer donors by PCR-SSP
method in people of Fars ethnicity living in Tehran, Iran.
Results: The most frequent alleles found were HLA-A*02(19.8%), HLA-A*03(13%), HLA-A*11 and -24 (12.5%),
HLA-B*35(17.7%) HLA-B*51(13.2%), HLA-DRB1*11(20.8%), whereas HLA-A*34 and HLA-A*44 (0.2%), HLA-B*47,
B*54, B*56, B*73(0.2%), and HLA-DRB1*09 (0.4%) were the least frequent alleles.
Conclusion: Identifying HLA allele frequencies in different ethnic groups, helps in designing a better plan for
development of donor centers in different provinces of a country, and a more precise prediction of donor size in the
registry, in addition to finding suitable donors for patients in need of hematopoietic stem cell transplantation.
Keywords: HLA, unrelated donors, ethnic groups, Iran
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Original Article |
Subject:
Pediatric Hematology & Oncology Received: 2013/01/26 | Accepted: 2015/01/3 | Published: 2015/01/3