Volume 7, Issue 3 (Spring 2015)                   Iranian Journal of Blood and Cancer 2015, 7(3): 119-128 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

S N. An Overview on Platelet-derived Microparticles in Platelet Concentrates: blood collection, method preparation and storage. Iranian Journal of Blood and Cancer 2015; 7 (3) :119-128
URL: http://ijbc.ir/article-1-614-en.html
Abstract:   (5436 Views)
Preparations of platelet concentrates (PCs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (PMPs) with high coagulant activity that may change platelet efficacy and safety issues. High shear stress could cause shedding of PMPs from the platelet plasma membrane, platelet aggregation, and activation of the coagulation cascade by increasing the catalytic phospholipid surface. These stresses may be prompted by processing and storage of blood and platelet rich plasma through various variables that has been fully described in this review. Depending on different rates of shear stress during processing and storage of PC, different quantities of MPs might be shed from platelets. On the other hand, the therapeutic effect of high levels of PMPs in PC has been reported for some patients. By using more sensitive and standardized methods for PMP measurement and change of platelet preparation process, further studies are required to monitor PMP generation during blood collection, processing and storage of PC to improve quality of PC and also in recipient’s reactions to transfusion. Keywords: Platelet-derived microparticle, Platelet concentrate, Blood collection, Platelet storage
Full-Text [PDF 297 kb]   (2062 Downloads)    
: Original Article | Subject: Pediatric Hematology & Oncology
Received: 2015/08/11 | Accepted: 2015/08/11 | Published: 2015/08/11

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 All Rights Reserved | Iranian Journal of Blood and Cancer

Designed & Developed by : Yektaweb