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IJBC 2015, 7(4): 179-183 Back to browse issues page
The Influence of Fetal Hemoglobin on Clinical and Hematological Variables of Children and Adolescents with Sickle Cell Anemia in Basra, Southern Iraq
AK Badr , MK Hassan *
Abstract:   (2727 Views)

Background: There are many parameters that modulate the severity of sickle cell anemia. Fetal hemoglobin (Hb F) is one of these major variables. However, its effect is clinically inconsistent. We conducted a descriptive study to assess the influence of Hb F on clinical events and hematological variables in patients with sickle cell anemia. Methods: 151 patients with sickle cell anemia with a stable condition, aged 1-18 years, were recruited from March through November 2010. The results of complete blood count and Hb F level and various clinical variables were recorded. Results: Of the 151 patients, the Hb F was more than 20%, 10-20%, and less than 10% in 77 (51%), 60 (39.7%), and 14 (9.3%) patients. A significant negative association was reported between Hb F level and frequency of painful crisis (95% CI=0.05-0.96, OR=0.22), acute chest syndrome (95% CI=0.01-0.43, OR=0.07) and frequency of hospitalizations (95% CI=0.03-0.85, OR=0.11). There was a significant positive association between hemoglobin level (95% CI=2.14-27.17, OR=7.63) and splenomegaly (95% CI=1.37-57.4, OR=12.88) with Hb F level. Conclusion: In children and adolescents with sickle cell anemia, the higher the Hb F levels, the lesser clinical complications of the disease would be. Therefore, patients with low Hb F need close follow-up and monitoring since early age to detect complications as early as possible and consider use of disease modifying agents.

Keywords: Sickle cell anemia, Fetal hemoglobin, Clinical severity, Complications
Full-Text [PDF 439 kb]   (1250 Downloads)    
: Research | Subject: Adults Hematology & Oncology
Accepted: 2015/10/20 | Published: 2015/10/6
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Badr A, Hassan M. The Influence of Fetal Hemoglobin on Clinical and Hematological Variables of Children and Adolescents with Sickle Cell Anemia in Basra, Southern Iraq. IJBC. 2015; 7 (4) :179-183
URL: http://ijbc.ir/article-1-628-en.html


Volume 7, Issue 4 (Summer 2015) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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