Cancer is a critical health threat in the world. It has an ongoing increasing trend.The aim of this study was to describe the trend, most common types of cancer and the gender ratio of cancer in Iran and its provinces. We searched PubMed, Google Scholar, Scopus, and Science directs from 2000 to 2017 using Keywords including “Cancer”, “Neoplasms”, “Malignancy”, “Tumor”, “Incidence”, “Epidemiology”, and “Iran”.The most common cancers of Iranian men were skin, stomach, bladder, prostate and colorectal cancers, respectively. The most common cancers of Iranian women were breast, skin, colorectal, stomach, and esophagus cancers, respectively. Cancer has an increasing trend in Iran. Cancer has more burden in the Northern and Northwest provinces of Iran. There was a notable diversity between the occurrences of different types of cancer between different provinces of Iran. Men were more predisposed to cancer. Iran experienced an increasing trend of cancer, like other countries. Different provinces of Iran experienced different patterns. The quality of cancer registry was different, also in many provinces, there were no strong epidemiological studies about cancer. The prevalence of some risk factors was differed in provinces.

Keywords: Neoplasms, Epidemiology, Incidence, Prevalence, Risk factors

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