Volume 12, Issue 1 ( March 2020 2020)                   Iranian Journal of Blood and Cancer 2020, 12(1): 29-33 | Back to browse issues page

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Fallah-Arzpeima S, Darbandi B, Hassanzadeh Rad A, Haghani Dogahe M, Niyasti P, Baghersalimi A. Multiple Cerebral Juvenile Xanthogranuloma; a Case Report. Iranian Journal of Blood and Cancer 2020; 12 (1) :29-33
URL: http://ijbc.ir/article-1-937-en.html
Multiple Cerebral Juvenile Xanthogranuloma; a Case Report
Sima Fallah-Arzpeima1 , Bahram Darbandi2 , Afagh Hassanzadeh Rad3 , Mohamad Haghani Dogahe4 , Parham Niyasti4 , Adel Baghersalimi * 5
1- Assistant Professor of Radiology, Department of Radiology, School of Medicine, Alzahra Hospital, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
2- Associated Professor of pediatric hematology and oncology, Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
3- PhD of Linguistics, Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
4- Student of Medicine, Guilan University of Medical sciences, Rasht, Iran
5- Assistant Professor of pediatric hematology and oncology, Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran , bahersalimi498@yahoo.com
Abstract:   (3112 Views)
Juvenile xanthogranuloma (JXG), is the most common form of non-Langerhans cell histiocytosis. It is a rare and usually benign, monoclonal proliferative disorder of histiocytic cells. The occurrence of multiple brain lesions is extremely rare. Due to the rarity of CNS disease, the preferred treatment and overall prognosis of these patients remain unclear. In this case report, authors present their experience about a patient with isolated multiple cerebral JXG which yields considerable outcomes. The patient was an eleven-year-old boy with anorexia and recurrent vomiting. Brain MRI demonstrated multiple lesions involving right lateral ventricle wall and periventricular white matter, the right side of splenium, mammillary body and tuber cinereum, fourth ventricle floor and roof, and cerebellar tonsil. After initial response to chemotherapy, the lesions recurred and radiotherapy was done. Consequent to good response after radiotherapy and despite the occurrence of a seizure attack, long term follow-up showed the marked resolution of the lesions and a good general status. 
Keywords: Juvenile xanthogranuloma, Child, Magnetic resonance imaging, Radiotherapy, Follow-Up
Full-Text [PDF 1572 kb]   (1201 Downloads)    
: Case report | Subject: Pediatric Hematology & Oncology
Received: 2019/09/17 | Accepted: 2020/04/19 | Published: 2020/05/2
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