en Pediatric Hematology & Oncology Pediatric Hematology & Oncology گزارش مورد Case report <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Arial;"><span style="font-size:14px;">Regular packed cell transfusion in patients with thalassemia major leads to iron overload. Chelation therapy is one of the important aspects of thalassemia care as iron overload causes significant cardiac, hepatic, and endocrine dysfunction. We report a case of thalassemia major with severe iron overload causing cardiac and liver dysfunction who benefitted from triple drug chelation therapy. Triple iron chelation therapy in thalassemia major could be suggested in severe iron overload patients.</span></span></span></p> Thalassemia major, Iron overload, Chelation therapy, Monotherapy, Triple iron chelation therapy 62 64 http://ijbc.ir/browse.php?a_code=A-10-562-1&slc_lang=en&sid=1 Ramitha R Bhat ramitha.rbhat@gmail.com 10031947532846009137 10031947532846009137 No Department of Pediatrics, Kasturba Medical College and Manipal Academy of Higher education (MAHE), Mangaluru, India Harshaprasada Lashkari harsha.pl@manipal.edu 10031947532846009138 10031947532846009138 Yes Department of Pediatrics, Kasturba Medical College and Manipal Academy of Higher education (MAHE), Mangaluru, India Stalin Ramprakash stalin.r@gmail.com 10031947532846009139 10031947532846009139 No Aster CMI hospital, Bangalore, India Diana Pereira dp201201@gmail.com5 10031947532846009140 10031947532846009140 No Regional advanced pediatric care center, Mangaluru, India