en Adults Hematology & Oncology Adults Hematology & Oncology مقاله مروری Review Article Thrombotic Thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathic disease, associated with thrombocytopenia and hemolytic anemia. It is caused by an enzymatic dysfunction responsible in cleavage of blood clotting factors. In this study we have tried to review the available approaches in diagnoses of the disease as well as treatment strategies. Based on the what the current review has provided, treatment policy depends on accurate diagnosis, it seems that developing a diagnostic and treatment guide for this disease is currently essential. Also, it’s necessary to study genetic types of TTP with more details because, hopefully, new techniques of gene therapy open a window to more stable treatments. Thrombotic thrombocytopenic purpura, Diagnosis, Gene therapy 111 120 http://ijbc.ir/browse.php?a_code=A-10-570-1&slc_lang=en&sid=1 Mohammadreza Saeidnia m.rezasaeednia@gmail.com 10031947532846006051 10031947532846006051 No Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran Faride Nam Avar Jahromi Faridehnamavar96@gmail.com 10031947532846006052 10031947532846006052 No Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran Elnaz Vaziee elivaziee@yhoo.com 10031947532846006053 10031947532846006053 No Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran Hossein Dehghani Dr.hosseind@gmail.com 10031947532846006054 10031947532846006054 No Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran Amir Mahmoodzade Amir.biochem@gmail.com 10031947532846006055 10031947532846006055 No Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Gholamhossein Tamaddon tamaddon.g@gmail.com 10031947532846006056 10031947532846006056 Yes Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran