Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1399
9
1
gregorian
2020
12
1
12
4
online
1
fulltext
en
Thrombotic Thrombocytopenic Purpura: Diagnosis and Treatment
Adults Hematology & Oncology
Adults Hematology & Oncology
مقاله مروری
Review Article
Thrombotic Thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathic disease, associated with thrombocytopenia and hemolytic anemia. It is caused by an enzymatic dysfunction responsible in cleavage of blood clotting factors. In this study we have tried to review the available approaches in diagnoses of the disease as well as treatment strategies. Based on the what the current review has provided, treatment policy depends on accurate diagnosis, it seems that developing a diagnostic and treatment guide for this disease is currently essential. Also, it’s necessary to study genetic types of TTP with more details because, hopefully, new techniques of gene therapy open a window to more stable treatments.
Thrombotic thrombocytopenic purpura, Diagnosis, Gene therapy
111
120
http://ijbc.ir/browse.php?a_code=A-10-570-1&slc_lang=en&sid=1
Mohammadreza
Saeidnia
m.rezasaeednia@gmail.com
10031947532846006051
10031947532846006051
No
Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran
Faride
Nam Avar Jahromi
Faridehnamavar96@gmail.com
10031947532846006052
10031947532846006052
No
Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran
Elnaz
Vaziee
elivaziee@yhoo.com
10031947532846006053
10031947532846006053
No
Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein
Dehghani
Dr.hosseind@gmail.com
10031947532846006054
10031947532846006054
No
Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran
Amir
Mahmoodzade
Amir.biochem@gmail.com
10031947532846006055
10031947532846006055
No
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Gholamhossein
Tamaddon
tamaddon.g@gmail.com
10031947532846006056
10031947532846006056
Yes
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran