Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1399
12
1
gregorian
2021
3
1
13
1
online
1
fulltext
en
Acute Lymphoblastic Leukemia Switch Lineage upon Relapse to Acute Bilineage Leukemia: A Case Report
Adults Hematology & Oncology
Adults Hematology & Oncology
گزارش مورد
Case report
<div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Arial;"><span style="font-size:14px;">Although acute leukemia commonly relapses in adults, the conversion of leukemic cell lineage (lymphoid or myeloid) upon relapse has rarely taken place. “Lineage switch” is a term widely used to define the leukemic lineage transformation as assessed by morphology, cytochemistry, and immunophenotyping from diagnosis to relapse. In most lineage switch cases, B-cell lymphoblastic leukemia/lymphoma relapses as acute myeloid leukemia or vice versa. Here, we report an exceedingly rare case of T-cell acute lymphoblastic leukemia relapsing as mixed-phenotype acute leukemia.</span></span></span></div>
Acute lymphoblastic leukemia (ALL), Lineage switch, Mixed-phenotype acute leukemias (MPALs), Acute bilineage leukemia
22
25
http://ijbc.ir/browse.php?a_code=A-10-583-1&slc_lang=en&sid=1
Valiollah
Mehrzad
10031947532846009163
10031947532846009163
No
Hematology Division of Internal Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran
Pardis
Nematollahi
10031947532846009164
10031947532846009164
Yes
Pathology Department, OMID Professional Hospital, Isfahan University of Medical Science
Anahita
Emami
10031947532846009165
10031947532846009165
No
Hematology Division of Internal Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran
Sayyideh Forough
Hosseini
drhosseini.forough@gmail.com
10031947532846009166
10031947532846009166
No
Hematology Division of Internal Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran