Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1399
7
1
gregorian
2020
10
1
12
3
online
1
fulltext
en
What We Know of the Prognostic Value of Lymphopenia in SARS-CoV-2 Infection
Infectious Diseases
Infectious Diseases
مقاله مروری
Review Article
Background: Although by comparing the number of deaths to the total number of cases one may conclude that most of the infected cases are recovering, taking a look at the increasing statistics of deaths shows that SARS-CoV-2 continues to take its toll. Since lymphocytes are the main immune cells battling with rapidly evolving viruses, it comes as no surprise to assume that a decreased number of these propitious soldiers may contribute to poor prognosis of the wide range of viral infections, including COVID-19. <br>
Methods: To provide a better prospect representing the prognostic value of lymphopenia in COVID-19, we searched the national library of medicine Medline/PubMed and performed a meta-analysis of pertinent literature representing information on the lymphocyte count in COVID-19 patients. <br>
Results: The results of our meta-analysis revealed that the number of lymphocytes retains a specific clinical and biological significance in this infection and lymphopenia is seemingly an important hematological abnormality that contributes to mirror the evolution toward an unfavorable outcome. <br>
Conclusion: The rapidly evolving nature of COVID-19 together with relentless disclosure of novel findings denotes a major limitation to the current study, and further investigations in the field of prognostic biomarkers will definitively pave the way to better manage patients with severe COVID-19.
SARS-CoV-2, COVID-19, Prognosis, Lymphocyte, Lymphopenia, Meta-analysis
75
79
http://ijbc.ir/browse.php?a_code=A-10-512-2&slc_lang=en&sid=1
Atieh
Pourbagheri-Sigaroodi
Atips1991@gmail.com
10031947532846005913
10031947532846005913
No
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Davood
Bashash
David_5980@yahoo.com
10031947532846005914
10031947532846005914
Yes
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Meysam
Olfatifar
ol.meysam92@gmail.com
10031947532846005915
10031947532846005915
No
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sina
Salari
s.salari@sbmu.ac.ir
10031947532846005916
10031947532846005916
No
Department of Medical Oncology, Hematology and Bone Marrow Transplantation, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hassan
Abolghasemi
h.abolghasemi.ha@gmail.com
10031947532846005917
10031947532846005917
No
Pediatric Congenital Hematologic Disorders Research Center, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.