en Pediatric Hematology & Oncology Pediatric Hematology & Oncology پژوهشي Original Article <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Arial;"><span style="font-size:14px;"><strong>Background:</strong> prevention of stomatitis can significantly reduce the cost of treatment and even increase the survival rate of patients. considering large side-effects of chemotherapy induced stomatitis, the aim of current study was to investigate the effect of sage &nbsp;aqueous &nbsp;extracts on the prevention of pain associated with stomatitis in children with chemotherapy-dependent leukemia admitted to hematology department of Be&rsquo;sat Hospital in Hamadan during 1396.<br> <strong>Methods:</strong> This double-blind and clinical study was conducted on children admitted to hematology department of Be&rsquo;sat Hospital, Hamedan; during 1396. &nbsp;The mouth of all patients before and after the intervention was checked and recorded in the checklist in terms of severity of pain caused by stomatitis.<br> <strong>Results:</strong> Current study was conducted on 60 children aged 6 to 14 years old. Comparison of the severity of the pain in the intervention group before intervention was not significant but after the intervention it was significant (P<0.001). Comparison of pain intensity in the control group before intervention was not significant but after the intervention it was significant (P<0.001). Comparison of pain intensity between intervention and control groups before intervention was not significant but after intervention, it was significant (P<0.001).<br> <strong>Conclusion:</strong> According to results of current study, the aqueous extract of the sage has a significant effect on pain relief from stomatitis in patients undergoing chemotherapy.</span></span></span></p> Aqueous extract of the sage, Stomatitis, Chemotherapy, Children 67 71 http://ijbc.ir/browse.php?a_code=A-10-611-2&slc_lang=en&sid=1 Khodayar Oshvandi oshvandi2005@yahoo.com 10031947532846009066 10031947532846009066 No Professor, Department of Medical and Surgical Nursing, Mother and Child Care Research Center, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran Fariba Ebrahimi Horyat arash5920@yahoo.com 10031947532846009067 10031947532846009067 No Masters of Pediatric Nursing, Hamadan University of Medical Sciences, Hamadan, Iran Ramezan Kalvandi arash5920@yahoo.com 10031947532846009068 10031947532846009068 No Hamadan Agriculyural and Natural Resources Research and Education Center, Hamadan, Iran Hossein Esfahani arash5920@yahoo.com 10031947532846009069 10031947532846009069 No Department of Pediatric Nursing, Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Arash Khalili arash5920@yahoo.com 10031947532846009070 10031947532846009070 Yes Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran