en Adults Hematology & Oncology Adults Hematology & Oncology نامه به ویراستار Letter to Editor <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Arial;"><span style="font-size:14px;">Factor V deficiency and other rare bleeding disorder are scarcity and orphan bleeding disorders. Thus, general physicians may rarely encounter with these disorders in clinical practice. If we do not treat them satisfactorily, the hemorrhagic propensity of these diseases may be fatal. Rarity and distribution of affected patients in all countries in the world is one of problem in their clinical practice. In reality, the distribution of small number and various type of coagulation factor concentrates for rare bleeding disorders in a wide country is troublesome in practice for health provider systems.</span></span></span></p> Factor V deficiency, Recombinant factor V concentrarte 148 148 http://ijbc.ir/browse.php?a_code=A-10-12-1&slc_lang=en&sid=1 Hassan Mansouritorghabeh mansouritorghabeh@mums.ac.ir 10031947532846009062 10031947532846009062 Yes Immunology Research Center, Inflammation and Inflammatory Disease Division, Mashhad University of Medical Sciences, Mashhad, Iran