Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1387
12
1
gregorian
2009
3
1
1
3
online
1
fulltext
en
Correlation of Serum Ferritin Level with Cardiac Function in β-Thalassemia Major
Pediatric Hematology & Oncology
Pediatric Hematology & Oncology
پژوهشي
Original Article
<p><strong>Background:</strong> The most important problem in regular transfusion dependent β-thalassemia major is cardiac dysfunction due to iron deposition in it. The aim of this study was to evaluate correlation between serum ferritin levels and cardiac function in β-thalassemia major in Mofid Hospital. <strong>Materials and Methods:</strong> There were 112 β-thalassemia patients with a mean age of 13.55± 6.12 years, of whom 49 were males and 63 were females. Patients enrolled in this study were divided into two groups group 1 (n=33) who were good users of chelation therapy with ferritin levels of <1500 ng/dl and group 2 (n=79) who were not good users of chelation therapy with ferritin levels more than 1500 ng/dl. Clinical history, physical examination, and laboratory investigations along with serum ferritin levels and echocardiography were assessed for all patients. <strong>Results:</strong> Overall ferritin levels were 200-8600 ng/dl. Mean ejection fraction was 64.72% and 63.30% in groups 1 and 2, respectively. There was not a significant difference between two groups. Mean fractional shortening were 29.30% and 28.82% in groups 1 and 2, respectively. Again there was not a significant difference. </p><p><strong>Conclusion:</strong> This study has shown that there was no significant correlation between echocardiographic indices and serum ferritin levels in major β-thalassaemia. Thus, other methods should be used to evaluate cardiac iron burden. </p>
Beta-thalassaemia, Echocardiography, Ferritin
103
107
http://ijbc.ir/browse.php?a_code=A-10-2-12&slc_lang=en&sid=1
Hassan
Mahmoodi Nesheli
1003194753284600122
1003194753284600122
Yes
Mohammad Taghi
Arzanian
1003194753284600123
1003194753284600123
No
Tahereh
Galini Moghaddam
1003194753284600124
1003194753284600124
No
Bibi Shahin
Shamsian
1003194753284600125
1003194753284600125
No
Samin
Alavi
1003194753284600126
1003194753284600126
No
Latif
Gachkar
1003194753284600127
1003194753284600127
No
Said
Mojtahedzadeh
1003194753284600128
1003194753284600128
No
Karimollah
Hajian Tilaki
1003194753284600129
1003194753284600129
No