en Pediatric Hematology & Oncology Pediatric Hematology & Oncology پژوهشي Original Article <p><strong>Background:</strong> The most important problem in regular transfusion dependent β-thalassemia major is cardiac dysfunction due to iron deposition in it. The aim of this study was to evaluate correlation between serum ferritin levels and cardiac function in β-thalassemia major in Mofid Hospital. <strong>Materials and Methods:</strong> There were 112 β-thalassemia patients with a mean age of 13.55± 6.12 years, of whom 49 were males and 63 were females. Patients enrolled in this study were divided into two groups group 1 (n=33) who were good users of chelation therapy with ferritin levels of <1500 ng/dl and group 2 (n=79) who were not good users of chelation therapy with ferritin levels more than 1500 ng/dl. Clinical history, physical examination, and laboratory investigations along with serum ferritin levels and echocardiography were assessed for all patients. <strong>Results:</strong> Overall ferritin levels were 200-8600 ng/dl. Mean ejection fraction was 64.72% and 63.30% in groups 1 and 2, respectively. There was not a significant difference between two groups. Mean fractional shortening were 29.30% and 28.82% in groups 1 and 2, respectively. Again there was not a significant difference. </p><p><strong>Conclusion:</strong> This study has shown that there was no significant correlation between echocardiographic indices and serum ferritin levels in major β-thalassaemia. Thus, other methods should be used to evaluate cardiac iron burden. </p> Beta-thalassaemia, Echocardiography, Ferritin 103 107 http://ijbc.ir/browse.php?a_code=A-10-2-12&slc_lang=en&sid=1 Hassan Mahmoodi Nesheli 1003194753284600122 1003194753284600122 Yes Mohammad Taghi Arzanian 1003194753284600123 1003194753284600123 No Tahereh Galini Moghaddam 1003194753284600124 1003194753284600124 No Bibi Shahin Shamsian 1003194753284600125 1003194753284600125 No Samin Alavi 1003194753284600126 1003194753284600126 No Latif Gachkar 1003194753284600127 1003194753284600127 No Said Mojtahedzadeh 1003194753284600128 1003194753284600128 No Karimollah Hajian Tilaki 1003194753284600129 1003194753284600129 No