Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1401
6
1
gregorian
2022
9
1
14
3
online
1
fulltext
en
Role of Molecular Biomarkers in Colorectal Cancer
Pathology
Pathology
مقاله مروری
Review Article
<p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Arial;"><span style="font-size:14px;"><span style="background:white"><span new="" roman="" times=""><span style="color:black">Colorectal cancer (CRC) is amongst the most widespread cancers and is a most common cause of cancer associated mortality universally. Since previous decades, it has been cleared that CRC develops owing to the buildup of a series of genetic and epigenetic changes in the normal colonic epithelium. Regardless of the current development in surgery and therapies, overall survival of end stage CRC patients is extremely low. Different biomarkers are valuable means found in tissue, blood, or stool samples usually, they are efficiently used for CRC monitoring, because they occur in initial stage of disease and provide better identification, diagnosis, prognostication, and prediction of cancer. </span></span></span><span new="" roman="" times="">An accurate biomarker-based treatment and prediction approach will help Patients to get rid of unsuccessful treatments, involving clinical trial-based methods. It will also definitely inhibit under and over dosages of treatment as well as it will decrease pointless harmful side effects.<span style="background:white"><span style="color:black"> This review focusses upon epidemiology, risk factors, molecular pathways, as well as Different DNA biomarkers and RNA biomarkers related to CRC. In this review, we will highlight the existing knowledge and advances in DNA based biomarkers (RAS, BRAF, cell free DNA, DNA methylation-based biomarkers, and Microsatellite Instability) and RNA-based biomarkers (MicroRNAs, non-coding RNAs, circular RNAs and PiRNAs) for CRC. Herein, we put emphasis for gathering of the latest facts related to biomarkers for obtaining their maximum possible advantages by promoting the clinical practice. New studies show the frequent usage of biomarkers, which will help in optimizing the best possible treatment approaches ultimately.</span></span><span style="background:white"></span></span><br>
</span></span></span></p>
Colorectal cancer, DNA biomarkers, RNA biomarkers, Cancer diagnosis.
41
56
http://ijbc.ir/browse.php?a_code=A-10-871-1&slc_lang=en&sid=1
Muhammad Junaid
Iqbal
junaidiqbal837@gmail.com
10031947532846008871
10031947532846008871
Yes
Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan
Shaifa
Saleem
sshaifa33@gmail.com
10031947532846008872
10031947532846008872
No
School of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan
Uroosa
Sarfraz
uroosa.sarfraz@gmail.com
10031947532846008873
10031947532846008873
No
Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan
Sania
Saeed
ssaniasaeed0@gmail.com
10031947532846008874
10031947532846008874
No
Department of Biological Sciences, International Islamic University Islamabad, Islamabad, Pakistan
Aghna
Maryam
maryamaghna@gmail.com
10031947532846008875
10031947532846008875
No
Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan