en Methodology Methodology <p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Arial;">Clustered Regularly Interspaced Palindromic Repeats (CRISPR) technology is an innovative gene-editing technique that has emerged as a result of the development of genetic engineering. This technology has expanded the scope of oncology-related medical research and clinical applications. CRISPR is used in molecular techniques to decode genes and pathways, alter the expression of specific genes for therapeutic purposes, and comprehend the pathophysiology of cancer. If pre-clinical research with this technology is successful, it could lead to clinical trials and eventually be used in clinical therapy. To establish the CRISPR complex as a promising tool in oncology for effective clinical cancer therapy, a variety of CRISPR variants and applications, as well as numerous experimental techniques, are being developed at present. This review examines several CRISPR technology variations, their application in oncology, as well as the system&#39;s advantages and disadvantages in comparison to earlier gene-editing technologies. It also discusses the recently discovered capabilities of the technology and its potential future applications in oncology.</span></span></p> CRISPR technology, Gene editing, Cancer, Oncology, Molecular research, Clinical application 60 70 http://ijbc.ir/browse.php?a_code=A-10-903-1&slc_lang=en&sid=1 Muhammad Khairi Ahmad 10031947532846008657 10031947532846008657 No Department of Biomedical Sciences, Advanced Medical and Dental Institute, Sains@Bertam, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, MALAYSIA. Kumitaa Theva Das 10031947532846008658 10031947532846008658 No Department of Biomedical Sciences, Advanced Medical and Dental Institute, Sains@Bertam, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, MALAYSIA. Siti Razila Abdul Razak sitirazila@usm.my 10031947532846008659 10031947532846008659 Yes Department of Biomedical Sciences, Advanced Medical and Dental Institute, Sains@Bertam, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, MALAYSIA.