en Pathology Pathology <p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Arial;"><strong>Background:</strong> A Kikuchi&ndash;Fujimoto Disease (KFD) is a benign, self-limiting lymphadenopathy condition which mostly diagnosed by a pathologist due to a lymph node biopsy. In this study, we tried to report a case of KFD in a 38-year-old Iranian woman. Furthermore, an evaluation of some genetic polymorphisms in the patient&rsquo;s peripheral blood was performed.<br> <strong>Case presentation:</strong> The patient was a 38-year-old female with a background of systemic lupus erythematosus, hypertension, hypothyroidism, and type 2 diabetes. The patient was under antibiotic treatment which was without any results. So she was referred to the rheumatology department for more evaluation. The patient went through various tests, Furthermore, the lymph node biopsy confirmed KFD. We could not find the EBV genome in the patient&rsquo;s serum. The polymorphisms evaluation revealed wild-type alleles in all rs78460947 in OR8U8, rs34068039 in RIOX1, rs2799077 in ZSCAN26, and rs2273346 in MASP-2 but some other polymorphisms in OR8U8 gene. Patient treatment was performed by the lymph node excision during sampling and anti-inflammation.<br> <strong>Conclusion:</strong> KFD is a rare disease in Iranian patients. No specific Polymorphisms could be found in this study in KFD except in the OR8U8 gene. Further evaluation of these polymorphisms provides a diagnostic or prognostic tool for KFD by more comprehensive studies.</span></span></p> Kikuchi–Fujimoto, Disease lymphadenopathy, Systemic lupus erythematosus 10 16 http://ijbc.ir/browse.php?a_code=A-10-957-1&slc_lang=en&sid=1 Ali Gholami dr.ali.gholami.arak@gmail.com 10031947532846009203 10031947532846009203 No School of Medicine, Arak University of Medical Sciences, Arak, Iran Baharak Tasorian bhrktsn2002@gmail.com 10031947532846009204 10031947532846009204 No Department of Rheumatology, Arak University Of Medical Sciences, Arak, Iran Amir Vard alirezatabibzadeh@gmail.com 10031947532846009205 10031947532846009205 No Department of pathology, Arak University of Medical Sciences Parastoo Yousefi parastoo_y@yahoo.com 10031947532846009206 10031947532846009206 No Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Alireza Tabibzadeh alireza.tabibzadeh@outlook.com 10031947532846009207 10031947532846009207 Yes Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran