en Pediatric Hematology & Oncology Pediatric Hematology & Oncology پژوهشي Original Article <div style="BORDER-BOTTOM: black 1pt solid BORDER-LEFT: medium none PADDING-BOTTOM: 1pt PADDING-LEFT: 0cm PADDING-RIGHT: 0cm BORDER-TOP: medium none BORDER-RIGHT: medium none PADDING-TOP: 0cm mso-element: para-border-div mso-border-bottom-alt: solid black .75pt"><p style="MARGIN: 0cm 0cm 3pt" class="IJBC-AbstractBody"><font size="2"><font face="Calibri"><b>Background: </b>To study methaemoglobin content and NADH-methaemoglobin reductase activity of three human erythrocyte genotypes (HbAA, HbAS and HbSS).</font></font></p><p style="MARGIN: 0cm 0cm 3pt" class="IJBC-AbstractBody"><font size="2"><font face="Calibri"><b>Materials and Methods: </b>Studies to ascertain methaemoglobin concentration and level of NADH-methaemoglobin reductase activity of three human erythrocyte genotypes (HbAA, HbAS and HbSS) were carried out in forty-three (43) healthy male participants of confirmed erythrocyte genotypes: HbAA (N=15), HbAS (N=15) and HbSS (N=13). Spectrophotometric method was used for determination of the two erythrocyte parameters. </font></font></p><p style="MARGIN: 0cm 0cm 3pt" class="IJBC-AbstractBody"><font size="2"><font face="Calibri"><b>Results: </b>Whereas methaemoglobin concentrations in the three erythrocyte genotypes was in the order: HbAS<hbaa<hbss, style="mso-bidi-font-style: normal" >p</i />>0.05) in methaemoglobin concentration and NADH-methaemoglobin reductase activity between HbAA and HbAS erythrocytes.</font></font></p><p style="MARGIN: 0cm 0cm 3pt" class="IJBC-AbstractBody"><font size="2"><font face="Calibri"><b>Conclusion: </b>The results showed a relationship between erythrocyte NADH-methaemoglobin reductase activity and methaemoglobin concentration.<b /></font></font></p><p></p><p></p><p></p></div> Methaemoglobin, Erythrocyte, Genotype, NADH-methaemoglobin Reductase 1 6 http://ijbc.ir/browse.php?a_code=A-10-2-161&slc_lang=en&sid=1