en Pediatric Hematology & Oncology Pediatric Hematology & Oncology پژوهشي Original Article Background: Bone sarcomas are the most common malignancies of bone tissues in children, and are classified into<br>two groups as osteosarcoma and Ewing’s Sarcoma. Treatment and prognosis depend on the subtype and grade of<br>the tumor. The goal of this study was to evaluate the features bone sarcoma in patients referred to MAHAK children<br>hospital since 2007 to 2009.<br>Materials and Methods: This was a retrospective study of patients with bone sarcoma referred to MAHAK<br>children hospital for continuing their treatment or as a new case of cancer. All of the patients had local pain, local<br>swelling, and decreased range of motion and pathologic fractures as the presenting symptom. All patients underwent<br>bone scan, chest computed tomography (CT) scan, chest X- ray, echocardiography, hearing tests, and bone<br>marrow aspiration/biopsy. All of the data were analyzed by SAS software.<br>Results: In this study, 36 patients with bone sarcoma were included with the age range of 3 to 20 years old (55% male<br>and 45% female). Analysis showed that local pain and local swelling were the most frequent local manifestations in<br>patients. The most common primary tumor site was distal femur (30%). Treatment for the patients at MAHAK<br>children hospital is performed according to German protocol. Out of 36 patients, 75% were followed until 2008 and<br>25% until 2009.<br>Conclusion: According to the analysis we can conclude that these data are similar to other studies. To achieve the<br>best results, oncologists have to modify the treatment of patients completely. Sarcoma, Manifestations, Protocol 81 86 http://ijbc.ir/browse.php?a_code=A-10-2-175&slc_lang=en&sid=1