en Pediatric Hematology & Oncology Pediatric Hematology & Oncology پژوهشي Original Article Non Hodgkin Lymphomas (NHL) are nodal or extra nodal monoclonal infiltrations by malignant lymphoid cells (B Lymphocytes in 80% of cases), which are distinguished as indolent or aggressive forms. According to the heterogeneity of lymphoid cells and their ubiquitous anatomical distribution, these disorders can develop in any organ and have very heterogeneous clinical expressions, but they are usually expressed by tumor development in the lymphoid tissue (lymph nodes, Waldeyer ring, spleen, bone marrow and sometimes blood). We report a patient referred to the department of hematology and bone marrow transplantation with an unusual localization for this type of pathology: eye localized phenotype B lymphoma in its aggressive form, occurring in a 88 years old man. Clinical remission was obtained by using rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone protocol combined with radiotherapy. Keywords: Non Hodgkin lymphoma, aggressive, eye, remission. Non Hodgkin lymphoma, aggressive, eye, remission. 77 81 http://ijbc.ir/browse.php?a_code=A-10-1-34&slc_lang=en&sid=1 Abdessamad Arabi 10031947532846002073 10031947532846002073 Yes Abdelbaki Boukerche 10031947532846002074 10031947532846002074 No Mohamed Bey 10031947532846002075 10031947532846002075 No Samira Bouchama 10031947532846002076 10031947532846002076 No Lila Charef 10031947532846002077 10031947532846002077 No Mohamed-Amine Bekadja 10031947532846002078 10031947532846002078 No