Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1393
8
1
gregorian
2014
11
1
7
1
online
1
fulltext
en
The Frequency of Genotype D of Hepatitis B Virus in Isfahan, Iran
Pediatric Hematology & Oncology
Pediatric Hematology & Oncology
پژوهشي
Original Article
Background: Approximately 600,000 deaths occur every year as a result of the acute and chronic consequences of hepatitis B virus infection. Ten different hepatitis B virus genotypes have been identified with distinct geographical distributions. Different clinical outcomes, including the rate of mutations, development of hepatocellular carcinoma, chronicity, response to treatment, transplantation rejection and occult infections, are affected by specific genotypes. The aim of the present study was to determine the frequency of genotype D of the virus in Isfahan, Iran.
Patients and Methods: In this study primarily hepatitis B virus positive patients were identified by the detection of HBs antigen using ELISA test and then PCR was used as a confirmatory test. Fifty five patients that were identified as hepatitis B positive were tested for hepatitis D genotype using type - specific PCR.
Results: The patients included 30 (54.5%) females and 25 (45.5%) males. In total, frequency of genotype D was 29 out of 55 cases (52.7%). Genotype D was detected in 19 (63.3%) females and 10 (40.0%) males indicating no statistically significant difference. The difference in the level of liver enzymes in patients infected with genotype D and non-genotype D hepatitis B virus were not significant.
Conclusion: In the present study the frequency of genotype D among patients with hepatitis B virus infection in Isfahan, Iran, was 52.7%. No significant relation was observed between the level of liver enzymes and infection with the genotype D.
Keywords: Hepatitis B virus, genotype D, PCR, Isfahan, Iran.
Hepatitis B virus, genotype D, PCR, Isfahan, Iran.
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29
http://ijbc.ir/browse.php?a_code=A-10-9-21&slc_lang=en&sid=1
Pazhouhnia
S
10031947532846002679
10031947532846002679
No
Bouzari
M
10031947532846002680
10031947532846002680
Yes
Rahimi
F
10031947532846002681
10031947532846002681
No
Kardi
MT
10031947532846002682
10031947532846002682
No