en اپاندیموما به عنوان بدخیمی ثانویه بعدازدرمان لنفوم غیرهوجکین Pediatric Hematology & Oncology Pediatric Hematology & Oncology گزارش مورد Case report <p>Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (Valporic acid, ATRA) are being investigated as potential treatments for the population of refractory cases of AML. Herein, we report a patient with primary refractory AML who was treated with oral low-dose chemotherapy after standard systemic chemotherapy.</p> Metronomic Chemotherapy, Histone deacetylase Inhibitor, Acute Myeloblastic Leukemia, Valporic acid, All-trans retinoic acid 231 234 http://ijbc.ir/browse.php?a_code=A-10-190-9&slc_lang=en&sid=1 Mahdi Shahriari 10031947532846003186 10031947532846003186 No babak abdolkarimi بابک عبدالکریمی b.abdolkarimi@yahoo.com 10031947532846003185 10031947532846003185 Yes pediatric hematology oncology fellowship فلوشیپ Fazl Saleh 10031947532846003187 10031947532846003187 No Pooria Salajeghe 10031947532846003188 10031947532846003188 No