en Diagnostic utility of bone marrow sampling and profile of hematological abnormalities in Indian HIV infected individuals Adults Hematology & Oncology Adults Hematology & Oncology پژوهشي Original Article <p></p> <p></p> <p></p> <p style="color: rgb(51, 51, 51); font-family: Tahoma, Arial, Verdana; font-size: 13px; line-height: 20.8px;"><strong>Objective</strong>: To evaluate the diagnostic utility of bone marrow (BM) sampling in HIV positive patients.</p> <p style="color: rgb(51, 51, 51); font-family: Tahoma, Arial, Verdana; font-size: 13px; line-height: 20.8px;"><strong>Background:&nbsp;</strong>Hematological abnormalities are a common complication of HIV infection and occur in all stages of the infection. These abnormalities increase as the disease advances.</p> <p style="color: rgb(51, 51, 51); font-family: Tahoma, Arial, Verdana; font-size: 13px; line-height: 20.8px;"><strong>Methods:&nbsp;</strong>40 HIV infected individuals were screened for hematological abnormalities. Investigations like iron studies, hematological work up, bone marrow evaluation and coagulation profile were performed.</p> <p style="color: rgb(51, 51, 51); font-family: Tahoma, Arial, Verdana; font-size: 13px; line-height: 20.8px;"><strong>Results:</strong>&nbsp;The most common single hematological abnormality was anemia, seen in 20% (8) patients. However, anaemia was seen as a subset of pancytopenia in 52.5% (21) patients. Microcytic hypochromic anemia was present in 30 % (12) cases while anemia of chronic disease (normocytic normochromic anemia) occurred in 10% (4) cases. Macrocytic anaemia was observed in 32.5% (13) cases. Leucopenia and thrombocytopenia were seen in 52.5% (21) patients as a subset of pancytopenia. However, they were not present as a single hematological abnormality. Majority of the patients [45% (18)] showed hypercellular marrow whereas normocellular marrow was seen in 35% (14) and hypocellular marrow in 15% (6) patients. Myelodysplasia was found in 25 % (10) of patients. It was commonest in granulocytic series 10% (4), followed by erythroid 12.5% (5) and megakaryocytic series 2.5% (1). &nbsp;Tuberculosis was seen in 4 cases and gelatinous transformation was seen in 2.5% (1) case.</p> <p style="color: rgb(51, 51, 51); font-family: Tahoma, Arial, Verdana; font-size: 13px; line-height: 20.8px;"><strong>Conclusion:&nbsp;</strong>Bone marrow sampling has diagnostic utility in HIV infected patients. Morphologic examination in HIV-positive patients plays a distinctive role in ruling out the presence of opportunistic infections.</p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p>Background: Hematological abnormalities are a common complication of HIV infection and occur in all stages of the infection. These abnormalities increase as the disease advances. We aimed to evaluate the diagnostic utility of bone marrow sampling in HIV-positive patients.<br> Methods: 40 HIV-infected individuals were screened for hematological abnormalities. Investigations such as iron studies, hematological work-up, bone marrow evaluation and coagulation profile were performed.<br> Results: The most common single hematological abnormality was anemia, seen in 8 (20%) patients. However, anemia was seen as a subset of pancytopenia in 21 (52.5%) patients. Microcytic hypochromic anemia was present in 12 (30%) cases while anemia of chronic disease (normocytic normochromic anemia) occurred in 4 (10%) cases. Macrocytic anemia was observed in 32.5% (n=13) cases. Leucopenia and thrombocytopenia was seen in 21 (52.5%) patients as a subset of pancytopenia. However, they were not present as a single hematological abnormality. 45% of the patients showed hypercellular marrow whereas normocellular marrow was seen in 35% (n=14) and hypocellular marrow in 15% (n=6) of the patients. Myelodysplasia was found in 10 (25%) patients. It was commonest in erythroid (12.5%) followed by myeloid series (10%) and megakaryocytic series (2.5%). &nbsp;Tuberculosis was seen in 10% of the cases and gelatinous transformation was seen in 1 (2.5%) case.&nbsp;<br> Conclusion: Bone marrow sampling has diagnostic utility in HIV-infected patients. Morphological examination in HIV-positive patients plays a distinctive role in ruling out the presence of opportunistic infections.</p> bone marrow, abnormalities, HIV patients 117 122 http://ijbc.ir/browse.php?a_code=A-10-282-1&slc_lang=en&sid=1 Sushma N Ramraje sushmaramraje@yahoo.com 10031947532846003521 10031947532846003521 Yes Associate Professor, Department of Pathology, Grant Govt. Medical College, Mumbai-400008, India Samir AH Ansari sushmaramraje@yahoo.com 10031947532846003522 10031947532846003522 No Assistant Professor, Department of Pathology, Grant Govt. Medical College, Mumbai-400008, India Snehal Kosale drsnehalk.pathology@gmai.com 10031947532846003523 10031947532846003523 No Department of Pathology, Grant Govt. Medical College, Mumbai-400008, India