Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1396
6
1
gregorian
2017
9
1
9
3
online
1
fulltext
en
Serum Levels of Glial Fibrillaryacidic Protein in Meningioma
Adults Hematology & Oncology
Adults Hematology & Oncology
پژوهشي
Original Article
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<p>Background: Glial fibrillaryacidic protein (GFAP), an intermediate filament protein, is mainly expressed by astrocytes, but some other cells like enteric glia and non-myelinating Schwann cells can also express GFAP. GFAP elevation has been reported in some types of meningioma and malignant brain tumors. In the present study, we analyzed the association between serum levels of GFAP with meningioma. <br>
Methods: Sixty-eight newly diagnosed patients with meningioma and 28 healthy individuals (control group) were included. Serum levels of GFAP were measured by ELISA.<br>
Results: There was no significant difference in GFAP serum levels between the two groups. Subdivision of the patients also revealed no significant association between GFAP and meningioma. <br>
Conclusion: We studied serum levels of GFAP in meningioma in Iranian patients for the first time. We did not observe a significant association between meningioma and GFAP. A larger study including a larger number of different subtypes of meningioma patients may discover a weakly significant difference if it exists.</p>
Brain, GFAP, Meningioma, Serum
75
79
http://ijbc.ir/browse.php?a_code=A-10-315-2&slc_lang=en&sid=1
Mohammad
Mehrazmay
mehrazmaym@sums.ac.ir
10031947532846003861
10031947532846003861
No
Shiraz University of Medical Sciences
Zahra
Mojtahedi
mojtahediz@sums.ac.ir
10031947532846003863
10031947532846003863
No
Shiraz University of Medical Sciences
Mahyar
Malekzadeh
malekzadehm@sums.ac.ir
10031947532846003864
10031947532846003864
No
Shiraz University of Medical Sciences
Musa
Taghipour
taghipourm@sums.ac.ir
10031947532846003862
10031947532846003862
No
Shiraz University of Medical Sciences
Abbas
Ghaderi
ghaderia@sums.ac.ir
10031947532846003860
10031947532846003860
Yes
Shiraz University of Medical Sciences