en Adults Hematology & Oncology Adults Hematology & Oncology پژوهشي Original Article <p style="margin: 0px; text-align: justify; line-height: 200%;">Background: Although several studies have been done on quality of life of patients with Sickle Cell Disease (SCD), there is little research on the correlation of health-related quality of life (HRQoL) with self-efficacy in these patients. We aimed to determine the association between HRQoL and self-efficacy in patients with SCD and to explore the role of self-efficacy and demographic-clinical variables in a sample of Iranian patients with SCD.<br> Methods: In this cross-sectional study, 97 SCD patients who had medical records in Shafa Hospital affiliated to the Ahvaz University of Medical Sciences were recruited. Data were collected using the Short-Form Health Survey SF-36 (RAND 36-item), the Sickle Cell Self-Efficacy Scale (SCSES) and a demographic-clinical information questionnaire during February to July 2013.<br> Results: The mean scores of physical and mental component summary of the SF-36 (PCS and MCS) was 45.58&plusmn;19.94 and 48.1&plusmn;19.63, respectively which were low in patients with SCD. Moreover, 50.5% of the patients reported a moderate level of self-efficacy (24.42&plusmn;6.59). Regression models showed that self-efficacy was the most important predictor of the mental component summary (MCS) (&beta;: 0.48, P=0.001). With a slight difference, it was the second strongest predictor of the physical component summary (PCS) (&beta;: 0.28, P=0.003), after the variable of &ldquo;renal disease history&rdquo; in the context of SCD (&beta;: -0.30, P=0.001). However, &ldquo;blood transfusion history&rdquo; was a common predictor for both the PCS (&beta;: 0.20, P=0.03) and the MCS (&beta;: 0.26, P=0.001) components of the HRQoL.<br> Conclusion: The results of this study can assist health policy makers and clinicians to plan holistic interventions by focusing on the level of self-efficacy in SCD patients.</p> Health-related quality of life, Self-efficacy, Sickle cell disease, Physical component, Mental component 1 8 http://ijbc.ir/browse.php?a_code=A-10-334-1&slc_lang=en&sid=1 Mehrnaz Ahmadi mer.ahmadi@gmail.com 10031947532846004076 10031947532846004076 No PhD. Student, Department of Nursing, Student Research Committee, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Camelia Rohani cameliarohani@yahoo.com 10031947532846004077 10031947532846004077 Yes PhD, Assistant Professor, Community Health Nursing Department, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Samira Beiranvand Beiranvandsamira@yahoo.com 10031947532846004078 10031947532846004078 No PhD, Student, Department of Nursing, Student Research Committee, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mahsa Matbooei mah.matbouei@gmail.com 10031947532846004079 10031947532846004079 No MSc, Community Health Nursing Department, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Saeed Poormansouri saeed.poormansouri@gmail.com 10031947532846004080 10031947532846004080 No MSc, Treatment Deputy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran