Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1396
12
1
gregorian
2018
3
1
10
1
online
1
fulltext
en
Correlation between Late-onset Neutropenia, Sepsis and Associated Factors in Preterm Infants: A single center study
Pediatric Hematology & Oncology
Pediatric Hematology & Oncology
پژوهشي
Original Article
Background: Late onset neutropenia (neutropenia after 3 weeks of life) may be a physiological condition without need to prescribe antibiotics, G-CSF, or IVIG. We aimed to determine the association between sepsis and late onset neutropenia in very low birth weight (<1500 gm) infants. <br>
Methods: This study was a cross-sectional prospective study in VLBW infants that were admitted in Mahdieh Hospital in Tehran/Iran. Complete blood count (CBC) was drawn at first day of admission and then weekly intervals until discharge from the hospital. In cases with neutropenia, CRP and blood cultures were assessed and correlation between clinical sepsis or positive blood culture and CRP with neutropenia was evaluated. <br>
Results: 219 VLBW infants during a period of 11 weeks were studied with serial weekly CBCs. 128 (58%) neonates had normal neutrophil counts, 91 (41.6%) had neutropenia, of which 28 (30.7%) had late onset neutropenia. Mean level of WBC was 5033.07±2037.57 cells/mm3 and mean level of ANC was 1757.75±944.32 cells/mm3. Positive blood culture at first week of life had significant correlation with neutropenia (P=0.001), but there was no significant correlation between late onset neutropenia and positive CRP (P=0.861), clinical symptoms of sepsis (P=0.5) and bacteremia (P=0.861). There was significant correlation between anemia (P<0.001) and IVH (P<0.007) without any significant correlation with asphyxia (P<0.223) and IUGR (P<0.123) with late onset neutropenia.<br>
Conclusion: VLBW infants admitted to the NICU with late onset neutropenia without symptoms of sepsis do not need any intervention and close observation with follow-up would be the most appropriate approach.<strong><span dir="LTR"></span></strong>
Late onset neutropenia, Prematurity, Sepsis, VLBW, IUGR, Asphyxia
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19
http://ijbc.ir/browse.php?a_code=A-10-351-1&slc_lang=en&sid=1
Minoo
Fallahi
minoofallahi@yahoo.com
10031947532846004087
10031947532846004087
Yes
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abolfazl
Afjeh
a.afjehi@gmail .com
10031947532846004088
10031947532846004088
No
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Naeemeh
Taslimi
naeemetaslimi@yahoo.com
10031947532846004089
10031947532846004089
No
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad
Kazemian
kazemianm @yahoo.com
10031947532846004090
10031947532846004090
No
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Masoumeh
Pandi
masoumepandi1394@gmail.com
10031947532846004091
10031947532846004091
No
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Saleheh
Tajalli
saleheh_tajalli@yahoo.com
10031947532846004092
10031947532846004092
No
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran