en Adults Hematology & Oncology Adults Hematology & Oncology پژوهشي Original Article Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma.<br> Methods: Methylation status of SMG1 promoter in 9 patients with multiple myeloma and 4 healthy subjects as control was determined by Methylation-specific PCR (MSP) method.<br> Results: SMG1 promoter in all myeloma patients was hemi-methylated. Meanwhile, in healthy subjects, two cases were hemi-methylated and the other two were normal.<br> Conclusion: The results of this study indicated that the prevalence of SMG1 promoter methylation in patients with multiple myeloma was higher than general population which could be important in understanding the pathogenesis of the disease. Multiple Myeloma, DNA methylation, SMG1 gene 114 116 http://ijbc.ir/browse.php?a_code=A-10-394-1&slc_lang=en&sid=1 Hamid Gholipour 10031947532846004546 10031947532846004546 No Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran Saeid Abroun 10031947532846004547 10031947532846004547 No Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran Mehrdad Noruzinia 10031947532846004548 10031947532846004548 No Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran Sasan Ghaffari 10031947532846004549 10031947532846004549 No Hematology Department, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran. Amirhosein Maali 10031947532846004550 10031947532846004550 No Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Mehdi Azad 10031947532846004551 10031947532846004551 Yes Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran