en Pediatric Hematology & Oncology Pediatric Hematology & Oncology پژوهشي Original Article Background: Frequent blood transfusions lead to various complications in&nbsp;patients with thalassemia major. Heart problems caused by iron deposition&nbsp;in the myocardium are the major cause of death in patients with thalassemia&nbsp;major. Early diagnosis of cardiac dysfunction in patients with thalassemia&nbsp;major undergoing frequent blood transfusion is very important. We aimed to investigate the correlation between serum Ferritin level, serum Troponin T (TropT), cardiac T2* MRI and echocardiographic findings in patients with&nbsp;thalassemia major.<br> Methods: This cross-sectional study was conducted on all children >5 years old with thalassemia major admitted to Amirkabir Hospital, Arak, Iran, during&nbsp;2016-2017. serum Ferritin level and Troponin T, echocardiography, and cardiac T2*MRI were analyzed in all participants.<br> Results: We found no correlation between serum ferritin and Trop T levels.&nbsp;However, there was a significant correlation between serum Trop T and&nbsp;serum ferritin with cardiac T2*MRI and also between serum Trop T and echocardiographic parameters (positive correlation with E/A ratio and functional shortening); and a negative correlation with left ventricular ejection fraction (LVEF). Moreover, there was no correlation between cardiac T2* MRI and echocardiographic findings.<br> Conclusion: Our results showed a positive correlation between serum troponin&nbsp;T with E/A size and FS and a negative correlation with LVEF and it was an&nbsp;important prognostic factor in early stage of cardiac damage in patients with&nbsp;thalassemia major. Moreover, there was a negative correlation between results of&nbsp;T2* MRI and serum ferritin and troponin T. Thalassemia major, Serum ferritin, Serum troponin T, T2*MRI, Echocardiography 1 5 http://ijbc.ir/browse.php?a_code=A-10-461-2&slc_lang=en&sid=1 Aziz Eghbali aziz_eghbali@yahoo.com 10031947532846005386 10031947532846005386 No Associate Professor, Department of Pediatrics, School of Medicine, Aliasghar clinical research development center, Iran University of medical sciences, Tehran, Iran. Sarvenaz Mehrabi sarvenazmehrabi@gmail.com 10031947532846005387 10031947532846005387 No Department of emergency, School of Medicine, Arak University of Medical Sciences, Arak, Iran Yazdan Ghandi Y.ghandi@arakmu.ac.ir 10031947532846005388 10031947532846005388 No Associate professor, Department of Pediatrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Aygin Eghbali aigineghbali@yahoo.com 10031947532846005389 10031947532846005389 No Students Research Committee, school of medicine, Iran university of Medical Sciences, Tehran, Iran Mona Dabiri Mona.dabiri@hotmail.com 10031947532846005390 10031947532846005390 No Department of emergency, School of Medicine, Arak University of Medical Sciences, Arak, Iran Morteza Mousavi_Hasanzadeh M.Mousavihasanzadeh @arakmu.ac.ir 10031947532846005391 10031947532846005391 Yes Students Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran.