en Pediatric Hematology & Oncology Pediatric Hematology & Oncology گزارش مورد Case report Juvenile xanthogranuloma (JXG), is the most common form of non-Langerhans cell histiocytosis. It is a rare and usually benign, monoclonal proliferative disorder of histiocytic cells. The occurrence of multiple brain lesions is extremely rare. Due to the rarity of CNS disease, the preferred treatment and overall prognosis of these patients remain unclear. In this case report, authors present their experience about a patient with isolated multiple cerebral JXG which yields considerable outcomes. The patient was an eleven-year-old boy with anorexia and recurrent vomiting. Brain MRI demonstrated multiple lesions involving right lateral ventricle wall and periventricular white matter, the right side of splenium, mammillary body and tuber cinereum, fourth ventricle floor and roof, and cerebellar tonsil. After initial response to chemotherapy, the lesions recurred and radiotherapy was done. Consequent to good response after radiotherapy and despite the occurrence of a seizure attack, long term follow-up showed the marked resolution of the lesions and a good general status.  Juvenile xanthogranuloma, Child, Magnetic resonance imaging, Radiotherapy, Follow-Up 29 33 http://ijbc.ir/browse.php?a_code=A-10-297-1&slc_lang=en&sid=1 Sima Fallah-Arzpeima simaazrpeyma@gmail.com 10031947532846005410 10031947532846005410 No Assistant Professor of Radiology, Department of Radiology, School of Medicine, Alzahra Hospital, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran Bahram Darbandi darbandi45@gmail.com 10031947532846005411 10031947532846005411 No Associated Professor of pediatric hematology and oncology, Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Afagh Hassanzadeh Rad afaghrad@gums.ac.ir 10031947532846005412 10031947532846005412 No PhD of Linguistics, Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Mohamad Haghani Dogahe mohamadhaghanidogahe@yahoo.com 10031947532846005413 10031947532846005413 No Student of Medicine, Guilan University of Medical sciences, Rasht, Iran Parham Niyasti pniyasti@gmail.com 10031947532846005414 10031947532846005414 No Student of Medicine, Guilan University of Medical sciences, Rasht, Iran Adel Baghersalimi bahersalimi498@yahoo.com 10031947532846005415 10031947532846005415 Yes Assistant Professor of pediatric hematology and oncology, Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran