Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1399
7
1
gregorian
2020
10
1
12
3
online
1
fulltext
en
Flow Cytometry in Chronic Myelogenous Leukemia Blast Crisis
Adults Hematology & Oncology
Adults Hematology & Oncology
پژوهشي
Original Article
Background: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder due to BCR-ABL1 translocation. Patients showing transformation into blast crisis (BC) have poorer treatment response and prognosis. <br>
Methods: A retrospective study was conducted in the department of Pathology, Maulana Azad Medical College, New Delhi, India, over a time period of 5 years (2014-2019) to evaluate the immunophenotypic features of the blast population. Twenty-one Cases of CML in BC were subjected for multiparametric flow cytometry. Data of the subjects in CML blast crisis was compiled and analyzed for the immunophenotypic categorization of the blast population. <br>
Results: The mean age of the patients at presentation was 39.84 years. Male to female ratio was 1:1.3. Out of 21 cases, 5 (23.8%) showed blasts of myeloid lineage, 8 (38%) myelomonocytic, 6 (28.5%) B lymphoid and 2 (9.5%) showed mixed lineage blast population. <br>
Conclusion: Blast lineage in blast crisis of CML is heterogeneous and may show antigens of more than one lineage. Hence, it is necessary to evaluate the immunophenotypic nature of the blasts for the best appropriate management of the patients accordingly.
Chronic myeloid leukemia, Blast crisis, Flow cytometric immunophenotyping, Prognosis, Immunophenotyping
80
83
http://ijbc.ir/browse.php?a_code=A-10-506-1&slc_lang=en&sid=1
Vindhyaprabha
Hegde
vindhyaprabhahegde@gmail.com
10031947532846005893
10031947532846005893
No
Department of Pathology Maulana Azad Medical College New Delhi
Sarika
Singh
sarikasingh97b@gmail.com
10031947532846005894
10031947532846005894
Yes
Department of Pathology, Maulana Azad Medical College, New Delhi, India
Pallavi
Sinha
pallavisinha43@gmail.com
10031947532846005895
10031947532846005895
No
Department of Pathology Maulana Azad Medical college New Delhi
Lity
Dhar
litydhar27@gmail.com
10031947532846005896
10031947532846005896
No
Department of Pathology Maulana Azad Medical college New Delhi
Sunita
Aggarwal
drsunita.mamc@gmail.com
10031947532846005897
10031947532846005897
No
Department of General medicine maulana Azad Medical college New delhi
Dharam Pal
Bhadoria
bhadoriadp@hotmail.com
10031947532846005898
10031947532846005898
No
Department of General Medicine Maulana Azad Medical college New Delhi
M K
Daga
drmraduldaga@gmail.com
10031947532846005899
10031947532846005899
No
Department of General Medicine Maulana azad Medical college New Delhi