en Adults Hematology & Oncology Adults Hematology & Oncology پژوهشي Original Article <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Arial;"><span style="font-size:14px;"><strong>Background:</strong> Several markers are investigated for prognostic purpose in CLL patients among which interleukin-10 (IL-10) is under more investigation. We aimed to study IL-10 level in a group of newly diagnosed patients with CLL in a single center in Alexandria, Egypt.<br> <strong>Methods:</strong> In this study, 80 newly diagnosed patients with CLL referring to Hematology Department of the Medical Research Institute of Alexandria University, Egypt, and a control group including 40 healthy volunteers were included. ZAP-70 was determined by flowcytometry and serum IL-10 concentration was measured using IL-10 sandwich ELISA method.<br> <strong>Results: </strong>Mean serum IL-10 levels were significantly higher among patients with CLL. IL-10 level was higher in those who were positive for ZAP-70, Binet stage C, Rai stage III-IV and patients with high scores for CLL prognostic index (&ge;8). It showed significant positive correlation with the percentage of ZAP-70 expression and significant negative correlation to hemoglobin and platelets count.<br> <strong>Conclusion:</strong> Serum IL-10 in patients with CLL at presentation could be used as a prognostic marker for disease progression. Measurement of IL-10 in low resources areas where flowcytometry is not available could be recommended as a substitute investigation.</span></span></span></p> Chronic lymphocytic leukemia, Egypt, IL-10 level, ZAP-70, Binet stage, Rai stage, Prognosis, Correlation 11 16 http://ijbc.ir/browse.php?a_code=A-10-555-1&slc_lang=en&sid=1 Waiel Mohmed Al-Kahiry kahiry13@gmail.com 10031947532846009154 10031947532846009154 Yes Department of Hematology, Faculty of Medicine and Health Sciences, University of Aden, Yemen Maha Abubakr Feissal Rabie maha.feissal@pua.edu.eg 10031947532846009155 10031947532846009155 No Department of Medical Laboratory Technology, Pharos University in Alexandria, Egypt Homam Mohamed Sharshira homamsharshira@yahoo.com 10031947532846009156 10031947532846009156 No Department of Hematology, Medical Research Institute, University of Alexandria, Egypt Amal Mostafa Ghanem dramalghanem@gmail.com 10031947532846009157 10031947532846009157 No Department of Hematology, Medical Research Institute, University of Alexandria, Egypt Maha Mohamed El-gammal mahagammal@yahoo.com 10031947532846009158 10031947532846009158 No Department of Hematology, Medical Research Institute, University of Alexandria, Egypt Irene Lewis Mikhael irene_saad@yahoo.com 10031947532846009159 10031947532846009159 No Department of Hematology, Medical Research Institute, University of Alexandria, Egypt دانشگاه اسکندریه