OTHERS_CITABLE
Complete Content of this Issue and Cover Content
http://ijbc.ir/article-1-642-en.pdf
2015-12-16
0
0
OTHERS_CITABLE
Bone Involvement in Neuroblastoma
http://ijbc.ir/article-1-640-en.pdf
2015-12-13
203
205
Fatima
Malek
fmalek7721@gmail.com
1
AUTHOR
Samin
Alavi
2
AUTHOR
REVIEW_ARTICLE
Treatment of Newly Diagnosed and Relapsed Hodgkin Lymphoma in Children
Hodgkin lymphoma (HL) accounts for about 10% of all childhood cancers. Five-year survival rates with modern therapies are now approaching >90-95% as a consequence of its significant sensitivity to both chemotherapy and radiation. The current challenge is to determine how much therapy is needed to improve survival and how to adapt treatment to the patient to prevent these long term toxicities. This challenge has resulted in the development of different strategies aimed at recognizing the optimal balance between preserving overall survival and avoidance of long-term treatment-related morbidity. Strategies in children could be quite different from those used for adults with HL. More defined risk stratification through imaging studies and biologic markers have been developped. Increased knowledge of the biology of HL have led to the introduction of targeted therapies in both the frontline and relapsed patients. Collaborative multicenter studies are required to develop new combination therapies for children with newly diagnosed and refractory HL.
http://ijbc.ir/article-1-641-en.pdf
2015-12-13
206
212
Diagnosed
Treatment
Children
Odile
Oberlin
Odile.oberlin@gustaveroussy.fr
1
AUTHOR
Catherine
Patte
2
AUTHOR
ORIGINAL_ARTICLE
تغییر در مسیر سیگنالی Wnt از طریق متیلاسیون ژن های SOX17 و RUNX3 در بیماران لوسمی حاد
http://ijbc.ir/article-1-630-fa.pdf
2015-12-13
213
219
لوسمی حاد میلوئیدی
لوسمی حاد لنفوبلاستیک
RUNX3
SOX17
DNA Methylation
Methylation Status of SOX17 and RUNX3 Genes in Acute Leukemia
Background: Several studies have examined the presence of DNA methylation of CpG islands in leukemia. Methylation of SOX17 and RUNX3 genes may play a role in leukemogenesis through silencing tumor suppressor genes. We investigated the methylation status of SOX17 and RUNX3 genes in patients with acute leukemia.
Methods: In this case-control study, peripheral blood samples from 100 AML and 100 ALL patients and 100 healthy controls were collected. Isolated DNA was treated with sodium bisulfite and methylation status was examined by methylation specific PCR (MS-PCR) with primers specific for methylated and unmethylated sequences of SOX17 and RUNX3 genes.
Results: The frequency of hypermethylation of SOX17 and RUNX3 genes were 36% and 28%I in patients with acute myeloid leukemia (AML), and 21% and 22% in patients with acute lymphoblastic leukemia (ALL), respectively. Aberrant methylation of these genes was found in all FAB classifications of AML and ALL. Hypermethylation of SOX17 (P=0.055) and RUNX3 (P=0.003) genes were associated with FAB-M0 and M1 subtypes of AML, respectively. Also, aberrant methylation of RUNX3 gene was associated with FAB-L1 subtype of ALL (P=0.053). There was not any significant association between hypermethylation of SOX17 and RUNX3 genes and clinical parameters of patients with leukemia including sex, age, WBC, and platelet counts.
Conclusion: Hypermethylation of SOX17 and RUNX3 genes was seen in patients with acute leukemia. Moreover, no significant association was observed between hypermethylation of SOX17 and RUNX3 and induction of remission.
http://ijbc.ir/article-1-630-en.pdf
2015-12-13
213
219
Acute myeloid leukemia
Acute Lymphoblastic leukemia
RUNX3
SOX17
DNA Methylation
Ali
Ghasemi
a.ghotaslou@gmail.com
1
1. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
AUTHOR
Abbas
Ghotaslou
a.ghotaslou@gmail.com
2
2. Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Kazem
Ghaffari
a.ghotaslou@gmail.com
3
3. Department of Hematology, School of Allied Medical Sciences, Arak University of Medical Sciences, Arak, Iran
AUTHOR
Mohsen
Mohammadi
a.ghotaslou@gmail.com
4
4. Department of Biotechnology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
بررسی متغیرها در بیماران Acute ITP
http://ijbc.ir/article-1-596-fa.pdf
2015-12-14
220
222
Correlation Between Demographic and Laboratory Variables in Adult Patients with Acute Idiopathic Thrombocytopenic Purpura in West Iran
Background: Idiopathic thrombocytopenic purpura is an autoimmune blood disorder in which platelet destruction is mediated by anti-platelet antibodies. There are two forms of ITP: acute and chronic. The aim of the present study was to evaluate the clinical variables in adult patients with acute ITP in west of Iran.
Patients and Methods: Medical records of adult patients with diagnosis of acute ITP referring to Hematology Clinic of Kermanshah from year 2004-2014 were analyzed. Demographic and hematologic data and status of H pylori infection of the patients were extracted.
Results: There were records of fifty-three patients diagnosed with acute ITP. Mean age at diagnosis was 39.1 years (±13.3) ranging from 14-68 years. Twenty patients (37.7%) were male. Out of 53 patients, 25 cases (47.2%) were positive for H pylori infection. There was significant association between Hb and platelet with sex of the patients (P;le0.05).
Conclusions: Mean age of adult patients with acute ITP was more than figures expected in chronic ITP patients. In addition, Prevalence of H pylori infection in acute ITP patients was more than chronic ITP patients.
http://ijbc.ir/article-1-596-en.pdf
2015-12-14
220
222
Idiopathic thrombocytopenic purpura
Helicobacter pylori infection
Acute
Chronic
Hemoglobin
WBC count
Mehrdad
Payandeh
md.payandeh@yahoo.com
1
Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Masoud
Sadeghi
sadeghi_mbrc@yahoo.com
2
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Edris
Sadeghi
sadeghi_mkn@yahoo.com
3
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Mostafa
Hossaini
mostafahossaini@yahoo.com
4
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
ORIGINAL_ARTICLE
تاثیر مقدار گلبول سفید در بیماران سکته قلبی
http://ijbc.ir/article-1-605-fa.pdf
2015-12-14
223
226
The Prognostic Value of White Blood Cells Count in Patients with Myocardial Infarction
Background: Ischemic heart disease and acute myocardial infarction is one of the most dramatic manifestations in one of the most investigated fields in the past few decades. In this study, the prognostic value of white blood cells count in patients with myocardial infarction (MI) was investigated in a six months follow-up.
Methods: In this cohort study, 106 patients with MI were investigated. White blood cell counts were assessed 48 hours after MI and the location of MI was determined using ECG. Mortality rate was determined and their correlation with leukocytosis was analyzed up to 6 months of follow-up. Binary logistic regression analysis was applied between factors such as mortality rate, location of the myocardial infarction, sex, hemoglobin and WBC count.
Results: Mean age of the patients was 62.5±13.3 years. 76.4% were men. 26% of patients had leukocytosis. Leukocytosis was significantly correlated with mortality in a six-month follow-up period (P<0.001). Fifteen (14.2%) patients died during the first three months of follow-up, of which 13 (86.7%) had leukocytosis. It was also shown that mean age of the patients and anemia in deceased group were significantly more than the survived group.
Conclusion: High WBC count in the first 48-h after MI can be regarded as a poor prognostic factor and it has an independent role in determining prognosis of patients with MI for the next six months.
http://ijbc.ir/article-1-605-en.pdf
2015-12-14
223
226
Leukocytosis
Mortality Rates
Myocardial Iinfarction
WBC Count
Prognostic factor
Ali
ShahriariAhmadi
shahriariahmadi@gmail.com
1
Department of Hematology-Oncology, Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Abdollah
Amirfarhangi
abdullah@yahoo.com
2
Department of Hematology-Oncology, Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Abbas
Gheisoori
gheisoori85245@yahoo.com
3
Department of Hematology-Oncology, Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mohsen
Arabi
mohsenarabi@yahoo.com
4
Department of Hematology-Oncology, Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Alireza
Mahmoudian
alireza.m@yahoo.com
5
Department of Hematology-Oncology, Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mehrdad
Payandeh
md.payandeh@yahoo.com
6
Department of Hematology-Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Masoud
Sadeghi
sadeghi_mbrc@yahoo.com
7
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
ORIGINAL_ARTICLE
Evaluating Blood Requests and Transfusion Practices in Widespread Surgical Procedures of Rasht Hospitals, Iran
http://ijbc.ir/article-1-610-fa.pdf
2015-12-14
227
230
Evaluating Blood Requests and Transfusion Practice in Major Surgical Procedures
Background: Red blood cell and other blood products play a crucial role in management of different disease processes, but in spite of implementation of crucial steps to improve the process of request for blood and blood consumption, there is still not enough information available regarding the proper practice in many medical centres. We aimed to evaluate the status of blood product requests and transfusion practice in surgical patients in Al-Zahra and 17th Shahrivar hospitals, Rasht, Iran.
Materials: This retrospective, descriptive cross-sectional study was performed using medical records of patients undergoing major surgical procedures in Al-Zahra and 17th Shahrivar hospitals, Rasht, Iran, from April to December 2013. The cross-match to transfusion ratio (C/T ratio), transfusion probability (T%) and transfusion index (TI) were analyzed. We used SPSS analytical software to analyze the data.
Results: Transfusion index was 0.27, transfusion probability 12.8% and C/T ratio was 7.38 which were higher than standards, indicating that only 54 units out of 399 red blood cells units requested were used. Laparoscopic surgery had the worst indicator in terms of wastage of packed cell products. These findings in 17th Shahrivar hospital were 0.09, 8.82% and 12.5, respectively. In this hospital only 10 units out of 125 requested units were used. Appendectomy showed the worst indicators.
Conclusion: Blood transfusion indexes particularly for laparoscopic and appendectomy procedures were high in two hospitals studied. In order to overcome this problems, providing teaching courses for proper transfusion practice in surgery departments to improve their knowledge of haemovigilance and preparation of defined guidelines for red blood cells’ cross matching and transfusion is recommended.
http://ijbc.ir/article-1-610-en.pdf
2015-12-14
227
230
Blood transfusion
Red blood cell
Surgery
Cross mach
haemovigilance
Iran
Blood request and utilisation
Sahar
Sheikhansari
1
Genaral Practitioner, school of medicine, Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Bahram
Darbandi
2
PediatricHematologist and Oncologist,:Pediatrics Growth Disorders Research Center, 17th Sharivar Hospital, school of medicine, Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Ziba
Zahiri Sorouri
3
AUTHOR
Adel
Bagheralimi
4
PediatricHematologist and Oncologist,:Pediatrics Growth Disorders Research Center, 17th Sharivar Hospital, school of medicine, Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
CASE_STUDY
اپاندیموما به عنوان بدخیمی ثانویه بعدازدرمان لنفوم غیرهوجکین
http://ijbc.ir/article-1-575-fa.pdf
2015-12-14
231
234
Metronomic Maintenance Therapy in Refractory Acute Myeloblastic Leukemia with Monosomy 7
Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (Valporic acid, ATRA) are being investigated as potential treatments for the population of refractory cases of AML. Herein, we report a patient with primary refractory AML who was treated with oral low-dose chemotherapy after standard systemic chemotherapy.
http://ijbc.ir/article-1-575-en.pdf
2015-12-14
231
234
Metronomic Chemotherapy
Histone deacetylase Inhibitor
Acute Myeloblastic Leukemia
Valporic acid
All-trans retinoic acid
Mahdi
Shahriari
1
AUTHOR
babak
abdolkarimi
b.abdolkarimi@yahoo.com
2
pediatric hematology oncology fellowship
AUTHOR
Fazl
Saleh
3
AUTHOR
Pooria
Salajeghe
4
AUTHOR
OTHERS_CITABLE
کواگولوپاتی مصرفی در بیمار با بروسلوزیس که ابتدا با ترومبوسیتوپنیک ترومبوتیک پورپورا اشتباه شد
http://ijbc.ir/article-1-546-fa.pdf
2015-12-14
235
236
DIC
TTP
Brucellosis
Disseminated Intravascular Coagulation in a Case of Brucellosis Misdiagnosed as Thrombotic Thrombocytopenia Purpura
http://ijbc.ir/article-1-546-en.pdf
2015-12-14
235
236
TTP
DIC
Brucellosis
Nasim
Valizadeh
nsedaha0@gmail.com
1
Tehran University of Medical Sciences
AUTHOR