Iranian Pediatric Hematology and Oncology Society
Iranian Journal of Blood and Cancer
2008-4595
2008-4609
11
2
2019
6
1
Assessment of Organ Specific Iron Overload in Transfusion-dependent Thalassemia by Magnetic Resonance Imaging Techniques
39
46
FA
Mozhgan
Hashemieh
Pediatric Hematologist and Oncologist, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Y
The consequence of repeated blood transfusions in thalassemia is iron overload in different organs. Magnetic resonance imaging (MRI) is a reliable, non-invasive and accurate method for iron detection in various tissues, hence the introduction of MRI has revolutionized the management of these patients and improved the life expectancy of them. Cardiac MRI T2* has a profound effect not only on estimation of severity of cardiac siderosis, but on intensification of chelation regimens and survival of patients. Liver hemosiderosis is also a common morbidity among thalassemia patients, since the liver represents the dominant iron storage organ in the body; however, the relationship between total body iron and liver iron concentration (LIC) is challenging. Pancreatic iron overload occurs in 75-100% of patients with thalassemia major, but the association between pancreatic R2* and development of diabetes mellitus has not been established in the studies. On the other hand, there is a strong correlation between pancreatic R2* and cardiac R2*, so pancreatic R2* could predict left ventricular function. The most prevalent endocrinopathy in patients with thalassemia is hypogonadotropic hypogonadism which has been correlated with pituitary iron overload. Published data about kidney and adrenal MRI is limited, and further studies are needed to determine their clinical significance.
Thalassemia major, Iron overload, Hemosiderosis, Magnetic resonance imaging, Liver, Heart, Pancreas, Adrenal
http://ijbc.ir/article-1-924-en.html
http://ijbc.ir/article-1-924-en.pdf
Iranian Pediatric Hematology and Oncology Society
Iranian Journal of Blood and Cancer
2008-4595
2008-4609
11
2
2019
6
1
Evaluating the Frequency of Human T-Lymphotropic Virus Type 1 Infection in Iranian Population
47
50
EN
Shirin
Ferdowsi
1. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine,
fedowsishirin@gmail.com
N
Mahsa
Najafzadeh
Birjand University of medical sciences, Birjand, Iran
N
Mohammad Reza
Ameli
Blood Transfusion Research Center, South Khorasan Regional Transfusion Center, Birjand, Iran
N
Seyed Mehdi
Sajjadi
Cellular and molecular research center, Birjand university o medical sciences
ferdowsishirin@gmail.com
Y
Background: Human T-cell lymphotropic viruses 1 (HTLV1) is endemic in specific regions. We aimed to determine the prevalence of HTLV I infection among blood donors in southeast Iran.
Methods: This cross-sectional study was conducted between April 2005 and March 2015. Sera were collected from blood donors and were tested for the presence of HTLV1 specific antibody using ELISA. Reactive samples were then tested by Western blot for confirmation.
Results: Of the 165,267 blood donors tested for HTLV 1 antibody, 45 (0.027%) donors were positive. Out of 45 positive donors, 41 were first time blood donors, 3 were repeat blood donors and 1 as regular donor. Most HTLV-1-positive donors were male and married. Co-infection with HBV was observed in one subject. The percentage of positive samples had increasing patterns from 0.016% in 2009 to 0.084% in 2010 and decreased after that to 0.014% in 2015.
Conclusion: The results indicated a low level of infection of HTLV1 in this part of our country.
HTLV infection, Blood donors, Prevalence, Seropositivity
http://ijbc.ir/article-1-866-en.html
http://ijbc.ir/article-1-866-en.pdf
Iranian Pediatric Hematology and Oncology Society
Iranian Journal of Blood and Cancer
2008-4595
2008-4609
11
2
2019
6
1
Deferoxamine Protective Effect in Preventing Nephrotoxicity in Children Under Treatment with Doxorubicin: A Randomized Clinical Trial
51
56
EN
Mohammadreza
Bordbar
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
mbordbar53@gmail.com
N
Fazl
Saleh
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
fazlsaleh@gmail.com
N
Omid Reza
Zekavat
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
ozekavat@gmail.com
N
Mitra
Basiratnia
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
basiratnia@sums.ac.ir
N
Gholamreza
Fathpour
Bushehr University of Medical Sciences, Bushehr, Iran
Dr.fathpour@yahoo.com
N
Soheila
Zareifar
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
zareifars@gmail.com
N
Mahdi
Shahriari
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
drmahdi.shahriari@gmail.com
N
Mehran
Karimi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
mkarimi820@gmail.com
N
Nader
Shakibazad
Assistant Professor of Pediatric Hematology and Oncology, Bushehr University of Medical Sciences, Bushehr, Iran
nshakibazad@gmail.com
Y
Background: Nephrotoxicity secondary to doxorubicin (DOX) may be associated with high morbidity and mortality rates. We aimed to assess the efficacy of Deferoxamine (DFO) in preventing DOX-induced nephrotoxicity in pediatric malignancy.
Methods: This Parallel-group randomized clinical trial was done on 62 children aged 2-18 years who had new onset malignancy treated with DOX. They were randomly assigned in three groups; group 1 (no intervention, n=21), group II (DFO 10 times DOX dose, n=20), group III (DFO 50mg/kg, n=21). Patients in the intervention groups received DFO concomitant with DOX 8-hour intravenous infusion in each chemotherapy course. Blood urea nitrogen, serum creatinine, electrolytes, calcium, phosphorus, magnesium and albumin levels, urine microalbumin, urine protein/creatinine ratio, and urine N-acetyl-β-D- glucosaminidase (NAG) as well as findings of kidney ultrasonography were compared between the groups after the last course of chemotherapy. The primary outcome was to compare the radiologic and serologic markers of glomerular and tubular damage between the 3 groups.
Results: Sixty patients were analyzed. Patients treated with DFO 10 times the dose of DOX had significantly lower urine NAG level compared to the control group (P=0.032). No significant renal damage was reported in their ultrasonography in the 3 groups. DFO was safely tolerated without any adverse effect.
Conclusion: DFO with 10-times the DOX dose may effectively prevent DOX-induced nephrotoxicity at least at the molecular level. Increasing the dose of DFO is not accompanied by better efficacy.
Trial registration: IRCT2016021915666N3
Deferoxamine, Doxorubicin, N- Acetyl -β -D- Glucosaminidase, Nephrotoxicity
http://ijbc.ir/article-1-878-en.html
http://ijbc.ir/article-1-878-en.pdf
Iranian Pediatric Hematology and Oncology Society
Iranian Journal of Blood and Cancer
2008-4595
2008-4609
11
2
2019
6
1
Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia
57
62
EN
Hoda
Enayati
MSc. Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
enayatih921@mums.ac.ir
N
Hossein
Ayatollahi
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
ayatollahihossein@yahoo.com
N
Mohammad Reza
Keramati
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
keramatimr@mums.ac.ir
N
Maryam
Sheikhi
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
sheikhim75@gmail.com
N
Hassan
Bagheri
BSc, Mashhad University of Medical Sciences, Mashhad, Iran.
bagherih2@mums.ac.ir
N
Seyyede Fatemeh
Shams
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
shams8869@yahoo.com
N
Mohammad Hadi
Sadeghian
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
sadeghianm100@yahoo.com
Y
Background: Acute lymphoblastic leukemia (ALL) results from genetic alterations in a single lymphoid progenitor cell. Expression of ROR1 is reported to be increased in ALL and mantle cell lymphoma. In this study the expression of ROR1 was assessed in newly diagnosed patients with ALL.
Methods: This study was carried out on 40 patients with newly diagnosed ALL and healthy individuals as control group. Quantification of ROR1 mRNA expression by Real Time quantitative PCR was performed. The expressions of ROR gene in patients were compared with the control group.
Results: ROR1 mRNA expression (Fold Changes) in patients with ALL was 2.85±3.51. ROR1 mRNA expression in patients with ALL was significantly higher than normal individuals (P<0.001). There was not any relationship between the expression of ROR1 and cytogenetic abnormalities.
Conclusion: We assessed ROR1 gene expression on mRNA of 40 ALL patients at diagnosis. The results showed that ROR1 expression had significant increase in ALL patients compared with healthy controls.
Acute lymphoblastic leukemia, Receptor tyrosine kinase-like orphan receptor 1, Gene expression
http://ijbc.ir/article-1-853-en.html
http://ijbc.ir/article-1-853-en.pdf
Iranian Pediatric Hematology and Oncology Society
Iranian Journal of Blood and Cancer
2008-4595
2008-4609
11
2
2019
6
1
Acute Skin and Pharynx Complications Following Adjuvant Hypofractionated Versus Conventional Radiotherapy in Patients
with Breast Cancer
63
68
EN
Amir
Ghasemi-Jangjoo
Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz, Iran. 2. Department of Radiology-Radiotherapy-Nuclear Medicine, Imam Reza hospital, Tabriz, Iran.
gasemijangjoo@tbzmed.ac.ir
N
Mohammad
Mirza-Aghazadeh-Attari
Aging research institute, Tabriz University of medical sciences, Tabriz, Iran.
m.aghazadeh75@yahoo.com
N
Seyed Ali
Mousavi-Aghdas
Aging research institute, Tabriz University of medical sciences, Tabriz, Iran.
mousavi.ag@tbzmed.ac.ir
Y
Background: Hypofractionated radiotherapy (HF) method was introduced to overcome the quickly growing tumor cells as well as shortening whole treatment course in solid tumors such as breast cancers. Here, we compared the incidence of dermatitis and pharyngitis among patients undergoing HF versus conventional fractionationated (CF) radiation therapy following surgery for breast cancer.
Methods: During this prospective study, women who had undergone breast surgery since 2015-2017 were included in the initial sample population. 40 patients were included for analysis in each arm of CF and HF. Patients treated by CF received 50 Gy with 2.0 Gy per each fraction session and in group of HF; 42.4 Gy was delivered in 2.66 Gy per fraction sessions for 3 months. Severity of acute dermatitis and pharyngitis was recorded for all patients in both groups based on regular examinations during and after the radiation therapy.
Results: 18 out of 40 patients in the conventional group experienced dermatitis of which 11 and 3 were grade 2 and 3, respectively. In the HF group, 8 experienced only grade 1 acute dermatitis. Thus, acute radiation-induced dermatitis occurred more frequently (P=0.017) and more severely (P=0.002) in the conventional group within 3 months of follow-up. There was no statistically significant difference in incidence of pharyngitis between the two groups.
Conclusion: There was a statistically significant difference in occurrence of dermatitis between the two groups of conventional radiotherapy and those who received hypofractionated radiation. Incidence and severity of dermatitis was more common in those who received conventional radiotherapy in comparison to hypofractionated method.
Conventional radiation therapy, Hypofractionationated radiotherapy, Breast cancer, Dermatitis, Pharyngitis
http://ijbc.ir/article-1-857-en.html
http://ijbc.ir/article-1-857-en.pdf
Iranian Pediatric Hematology and Oncology Society
Iranian Journal of Blood and Cancer
2008-4595
2008-4609
11
2
2019
6
1
Metastatic Renal Cell Carcinoma to the Humerus Bone: A Report of Two Cases
69
71
EN
Mazaher
Ramezani
Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
mazaher_ramezani@yahoo.com
N
Farideh
Baharzadeh
Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
faridbahar@yahoo.com
N
Homa
Hadidi
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
homa.hadidi@yahoo.com
N
Maryam
Mirzaei
olecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
dr.maryam.mirzaei67@gmail.com
N
Masoud
Sadeghi
edical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
sadeghi_mbrc@yahoo.com
Y
Renal cell carcinoma (RCC) is an aggressive malignancy which can metastasize to the bone. Long bones or the small bones of the limbs could be rarely the destinations for metastatic RCCs. We report two cases of metastatic RCC to the humerus bone with the initial presentation of pathological fracture. The pathologists must be aware of metastatic RCC to the arm and consider it in the differential diagnosis of any arm lesion with clear cell feature, whether there is a history of RCC or not. Complete clinical data and a history of the patient are of significant importance for pathologists to avoid unnecessary laboratory procedures.
Renal cell carcinoma, Metastasis, Bone, Humerus
http://ijbc.ir/article-1-851-en.html
http://ijbc.ir/article-1-851-en.pdf
Iranian Pediatric Hematology and Oncology Society
Iranian Journal of Blood and Cancer
2008-4595
2008-4609
11
2
2019
6
1
Immune Thrombocytopenia as a Primary Sign of Relapse in Hodgkin Lymphoma: A Case Report
72
74
EN
Hossein
Karami
Thalassemia Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran
karami_oncologist@yahoo.com
N
Mohammad
Naderisorki
Thalassemia Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran
dr.naderisorki@gmail.com
Y
Maryam
Ghasemi
Associate Professor of Pathology, Immunogenetics Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
N
Sayed Mohammad
Sakhaei
Assistant Professor of Interventional Radiology, Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
N
Hodgkin lymphoma (HL) as a malignant tumor presents with lymphadenopathy and systemic complaints. The origin of this tumor is mostly suggested to be B lymphocytes. There is a close relationship between autoimmunity and HL, but the mechanism of this immune syndromes is unclear. Immune thrombocytopenia (ITP) is the most common autoimmune syndrome which may present before, at the same time, and even after treatment of the HL. We present a case of ITP as a primary sign of relapse of HL in a 15-year-old boy after complete treatment of HL.
Hodgkin lymphoma, Immune thrombocytopenia, Relapse, Autoimmunity
http://ijbc.ir/article-1-917-en.html
http://ijbc.ir/article-1-917-en.pdf
Iranian Pediatric Hematology and Oncology Society
Iranian Journal of Blood and Cancer
2008-4595
2008-4609
11
2
2019
6
1
A Rare Disorder of Bleeding Tendency: Ehlers-Danlos Syndrome
75
76
FA
Parastou
Molaei Tavana
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Y
Samin
Alavi
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
N
http://ijbc.ir/article-1-925-en.html
http://ijbc.ir/article-1-925-en.pdf