2024-03-28T20:58:04+03:30 http://ijbc.ir/browse.php?mag_id=16&slc_lang=en&sid=1
16-569 2024-03-28 10.1002
Iranian Journal of Blood and Cancer Iranian Journal of Blood and Cancer 2008-4595 2008-4609 10.61186/ijbc 2011 4 1 Table of contents 2011 12 01 0 0 http://ijbc.ir/article-1-569-en.pdf
16-570 2024-03-28 10.1002
Iranian Journal of Blood and Cancer Iranian Journal of Blood and Cancer 2008-4595 2008-4609 10.61186/ijbc 2011 4 1 Members Information Pack 2011 12 01 0 0 http://ijbc.ir/article-1-570-en.pdf
16-369 2024-03-28 10.1002
Iranian Journal of Blood and Cancer Iranian Journal of Blood and Cancer 2008-4595 2008-4609 10.61186/ijbc 2011 4 1 Serum Antioxidant Levels in Children with Beta-Thalassemia Major L Farzin F Sajadi L Kupai Background: Thalassemia represents a serious health problem in Iran because of its heterogeneous frequency and the existing endogamy system. It is an inherited blood disease characterized by the under production of normal hemoglobin, the oxygen-carrying protein in red blood cells. Materials and Methods: In this study, serum antioxidants including selenium (Se), zinc (Zn) and copper (Cu) were measured using atomic absorption spectrometry (AAS) in children with beta-thalassemia major (n=40) and compared with the control group (n=40). Results: There were significant differences in the values of Se, Zn and Cu between the two groups. Se and Zn levels were 41.78±22.87 μg/l and 61.70±13.25 μg/dl in thalassemia, but 108.63±25.79 μg/l and 114.72±23.70 μg/dl in healthy children. Meanwhile, Cu levels were 156.60±22.62 and 102.88±31.15 μg/dl among patients and controls, respectively. Conclusion: This study shows that Se, Zn and Cu may play a role in the pathogenesis of beta-thalassemia major. Key words: Beta-thalassemia, antioxidants, children Beta-thalassemia antioxidants children 2011 12 01 1 5 http://ijbc.ir/article-1-369-en.pdf
16-370 2024-03-28 10.1002
Iranian Journal of Blood and Cancer Iranian Journal of Blood and Cancer 2008-4595 2008-4609 10.61186/ijbc 2011 4 1 Haemovigilance in Iran (First Report) M Faranoush F Jalali S Aminikafiabadi MR Balali A Azarkeivan B Hajibeigi M Paridar F Asgharipoor M Zadsar A Chegini Haemovigilance is a system with standard program to cover the entire transfusion chain, monitor, evaluate and analyse the data to improve patients’ safety. We report the implemented haemovigilance system in hospitals and transfusion reactions (TR) in Iran. Methods and Materials: This was a prospective descriptive study. The national reporting system for transfusion incidents was introduced in January 2009. In the period 2009- 2011, 47 hospitals in a mandatory manner reported transfusion incidents among patients to the blood bank in a mandatory manner. All incidents were anonymously recorded in a standardized report form and registered in 10 categories. Results: A total of 377 transfusion incidents were reported and categorized as: incorrect blood component transfused (n = 4), Febrile non hemolytic transfusion reaction (FNHTR) (n=84), Immune hemolytic transfusion reactions (n =12), nonimmune hemolytic transfusion reactions (n = 7), allergic reactions (n = 247), transfusion-related acute lung injury (n = 2). There were no reports in the categories of infections, post-transfusion purpura, transfusion-acquired viral infection, and transfusion-related graft versus host disease. Conclusion: Haemovigilance is a tool for quality improvement and better surveillance on patient safety. The safety and quality of blood transfusions can be improved if we follow the transfusion chain, prevent and treat transfusion reactions and report adverse reactions to change the protocols. Key Words: Adverse reaction, Blood Safety, Haemovgilance, Risk Adverse reaction Blood Safety Haemovgilance Risk 2011 12 01 7 11 http://ijbc.ir/article-1-370-en.pdf
16-371 2024-03-28 10.1002
Iranian Journal of Blood and Cancer Iranian Journal of Blood and Cancer 2008-4595 2008-4609 10.61186/ijbc 2011 4 1 Frequency of Decreased Bone Mineral Density and Its Risk Factors during Childhood among Iranian Hemophilia Patients Peyman Eshghi peyman64@yahoo.com Borhan Moradveisi This study was undertaken to assess the frequency of decreased bone mineral density and its risk factors as well as its impact on the quality of life during childhood among hemophiliac patients. Materials and Methods: Thirty seven children with severe hemophilia A and B, referred to Mofid Children’s Hospital during 2010, were selected. For all patients the joint score, body mass indexes, bone mineral density, the level of inhibitor antibodies were measured. Short forms of Haeamo-QoL questionnaire were used to assess their quality of life. Data were statistically analyzed using Kolmogorov-Smirnov Z, Mann-Whitney, T-test, Fisher’s eact test, and χ² test. Results: In this study the overall prevalence of low bone density was 35%. Factors that were significantly associated with the frequency and severity of decreased bone density were age, presence of inhibitor antibodies, and reduced joint range of motion. Total quality of life score, and the sub scores of “viewpoint” and “others” as well as the “attitude” were decreased significantly in patients with decreased bone density. Conclusion: According to our findings there is a high prevalence of low bone density among hemophiliac patients. The body mass index should be maintained by appropriate nutrition and exercise to prevent loss of bone density in patients with hemophilia. Prophylaxis regimen in early childhood and regular monitoring of inhibitor antibody development are advised for early detection and management of this complication. Key words: Hemophilia, antibody, body mass index, bone mineral density, quality of life Hemophilia antibody body mass index bone mineral density quality of life 2011 12 01 13 17 http://ijbc.ir/article-1-371-en.pdf
16-373 2024-03-28 10.1002
Iranian Journal of Blood and Cancer Iranian Journal of Blood and Cancer 2008-4595 2008-4609 10.61186/ijbc 2011 4 1 Epidemiological features of Central Nervous System tumors at MAHAK Pediatric Cancer Treatment and Research Center A Mehrvar M Faranoush AA Hedayati Asl M Tashvighi MA Fazeli N Mehrvar R Ravan Parsa B Sobuti A Jafarpour R Zangooei Background: In this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to MAHAK Pediatric Cancer Treatment and Research Center (one of the main national referral centers for childhood malignancies in Iran) for treatment. Materials and Methods: This cohort (simple sampling) study consisted of 198 children less than 15 year old with CNS tumor referred to MAHAK Pediatric Cancer Treatment and Research Center from 2007 to 2010. The unique checklist contained epidemiological features filled for each individual. Results: Out of studied patients 125(63.1%) were male and 73(36.9%) were female. The mean age of patients was 6.11±3.65 years. Tumors were located in supratentorial (N=60, 30.3%), infratentorial (N=134, 67.7%) and spinal (N=4, 2%) regions. High-grade glioma and medulloblastoma were the most common tumors in supratentorial and infratentorial locations respectively. The majority of patientin medulloblastoma group had T2M0 (N=44, 22.2%) stage. Thirty-one (15.7%) patients had arelapse. There were 38.4% treatment and 41.4% death. The five years survival rate among patients was 28%. Conclusion: The same frequency of CNS tumors in children less than 15 years old referred to MPCTRC was observed compared to other studies. The sex incidence, the mean age at presentation, tumor sites, brain tumor’s pathologies, signs and symptoms, metastases and relapses were also in line with other studies. There were significant differences in terms of high consanguinity rate and high incidence of familial cancer history as compared to reports from others. Keywords: Brain, tumor, infratentorial, supratentorial, spinal, treatment, childhood. Brain tumor infratentorial supratentorial spinal treatment childhood. 2011 12 01 19 23 http://ijbc.ir/article-1-373-en.pdf
16-372 2024-03-28 10.1002
Iranian Journal of Blood and Cancer Iranian Journal of Blood and Cancer 2008-4595 2008-4609 10.61186/ijbc 2011 4 1 Clear cell sarcoma of the hand: a case of malignant melanoma of soft parts R Tavakoli K Sheibani M Khayatkhoei A case is reported with clear cell sarcoma (CCS) of the hand. Early diagnosis of clear cell sarcoma is always difficult due to its slow growing nature, benign clinical appearance, lack of pigmentation in most cases, and relatively young age of patients which make it to clinically appear as a benign soft tissue tumor. We report a case of clear cell sarcoma of hand in a 56 year old male with a non-painful, soft tissue tumor. Following suspicious appearance, rapid growth of the tumor and complications due to limited movement of the fingers, it was decided to perform excisional biopsy in order to remove the tumor and perform histological assessment. According to microscopic findings and immunohistochemical results, clear cell sarcoma was diagnosed. Our case reminds that clear cell sarcoma can develop in locations such as hand and upper extremities which are not common places to find it, therefore it is important to consider clear cell sarcoma in differential diagnosis of malignancies in hand and upper extremities. Key Words: Clear Cell Sarcoma, Malignant Melanoma of Soft Parts, Metastasis, Skin Cancer Clear Cell Sarcoma Malignant Melanoma of Soft Parts Metastasis Skin Cancer 2011 12 01 25 30 http://ijbc.ir/article-1-372-en.pdf