en Infectious Diseases Infectious Diseases متا آنالیز Meta-analysis <p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:2;"><strong>Background: </strong>Cancer remains a major global health burden, and while conventional treatments like chemotherapy and immunotherapy have improved outcomes, they are limited by resistance and adverse effects. Bacterial-based cancer therapies (BBCTs) offer a promising alternative due to their tumor-targeting ability, immune modulation, and potential as therapeutic vectors.<br> <strong>Objective: </strong>This meta-analysis evaluates the efficacy and safety of BBCTs by analyzing tumor growth inhibition (TGI%) in preclinical models and progression-free survival (PFS), overall survival (OS), and optimal response rate (ORR) in clinical studies.<br> <strong>Methods:</strong> &nbsp;A systematic search of PubMed, Google Scholar, and Cochrane Library was conducted for relevant studies. Data on treatment efficacy and adverse events were extracted and statistically analyzed.<br> <strong>Results: </strong>BBCTs showed significant tumor suppression and survival benefits over controls. PFS consistently demonstrated tumor growth delay, and some OS values extended beyond 35 units, suggesting long-term benefit. However, variability in outcomes was noted, influenced by bacterial strain, tumor type, and immune response. Safety concerns, including toxicity and immune-related effects, were also observed.<br> <strong>Conclusion: </strong>BBCTs show strong therapeutic promise, but further clinical validation is needed to improve delivery, consistency, and safety. Personalized, translational research is key to bridging preclinical findings with clinical application.</span></span></span></p> Bacteria-based Carcinoma, Tumor, Therapeutics, Anticancer 102 113 http://ijbc.ir/browse.php?a_code=A-10-2044-1&slc_lang=en&sid=1 Prithpal Singh Matreja 100319475328460013160 100319475328460013160 No Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad, UP, India. Ajay Kumar 100319475328460013161 100319475328460013161 No Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad, UP, India. Vinod Kumar 100319475328460013162 100319475328460013162 No Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad, UP, India. Sudhir Singh singhdrsudhir4@gmail.com 100319475328460013163 100319475328460013163 Yes Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad, UP, India.