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Volume 14, Issue 1 ( March 2022 2022)
Iranian Journal of Blood and Cancer 2022, 14(1): 6-11 |
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Montazeri-Najafabady N, Dabbaghmanesh M H, Chatrabnous N, Arabnezhad M R, Mohammadian Amiri R. Mir 143 rs353293 G>A Polymorphism is Not Associated with the Risk of Thyroid Cancer in the Iranian Population: A Case-Control Study. Iranian Journal of Blood and Cancer 2022; 14 (1) :6-11
URL: http://ijbc.ir/article-1-1022-en.html
URL: http://ijbc.ir/article-1-1022-en.html
Nima Montazeri-Najafabady1 
, Mohammad Hossein Dabbaghmanesh * 2, Nazanin Chatrabnous1 , Mohammad Reza Arabnezhad1 , Rajeeh Mohammadian Amiri1
, Mohammad Hossein Dabbaghmanesh * 2, Nazanin Chatrabnous1 , Mohammad Reza Arabnezhad1 , Rajeeh Mohammadian Amiri1
1- Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2- Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , dabbaghm@sums.ac.ir
2- Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , dabbaghm@sums.ac.ir
Abstract: (1544 Views)
Background: Single nucleotide polymorphisms (SNPs) in the promoter region of miRNAs may disturb miRNAs processing, alter their expression, and ultimately affect an individual’s susceptibility to cancer. We conducted a case-control study to evaluate the association of rs353293 G>A with the risk of thyroid cancer in the Iranian population.
Methods: 192 patients with thyroid cancer including (papillary, follicular, medullary, and undifferentiated) and 125 healthy subjects were enrolled in this case-control study. rs353293 G>A polymorphism in the promoter region of miR-143/145 were analyzed using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) to find the association of this SNP with thyroid cancer. Logistic regression analyses were conducted to evaluate adjusted odds ratios (ORs) for the potential confounding factors (age and sex), and 95% confidence intervals (95% CIs) between patients with thyroid cancer and controls.
Results: We found no association between rs353293 G>A polymorphism and thyroid cancer.
Conclusion: This study suggests that the functional polymorphism in rs353293 is not associated with development of thyroid cancer. Future investigations with larger sample size should be performed to confirm our observations.
: Original Article |
Subject:
Genetics
Received: 2020/06/16 | Accepted: 2022/03/8 | Published: 2022/04/30
Received: 2020/06/16 | Accepted: 2022/03/8 | Published: 2022/04/30
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