:: Volume 13, Issue 1 (March 2021 2021) ::
IJBC 2021, 13(1): 22-25 Back to browse issues page
Acute Lymphoblastic Leukemia Switch Lineage upon Relapse to Acute Bilineage Leukemia: A Case Report
Valiollah Mehrzad, Pardis Nematollahi *, Anahita Emami, Sayyideh Forough Hosseini
Pathology Department, OMID Professional Hospital, Isfahan University of Medical Science
Abstract:   (813 Views)
Although acute leukemia commonly relapses in adults, the conversion of leukemic cell lineage (lymphoid or myeloid) upon relapse has rarely taken place. “Lineage switch” is a term widely used to define the leukemic lineage transformation as assessed by morphology, cytochemistry, and immunophenotyping from diagnosis to relapse. In most lineage switch cases, B-cell lymphoblastic leukemia/lymphoma relapses as acute myeloid leukemia or vice versa. Here, we report an exceedingly rare case of T-cell acute lymphoblastic leukemia relapsing as mixed-phenotype acute leukemia.
Keywords: Acute lymphoblastic leukemia (ALL), Lineage switch, Mixed-phenotype acute leukemias (MPALs), Acute bilineage leukemia
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: case report | Subject: Adults Hematology & Oncology
Received: 2020/06/20 | Accepted: 2021/04/6 | Published: 2021/05/23

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Volume 13, Issue 1 (March 2021 2021) Back to browse issues page