Factor V deficiency and other rare bleeding disorder are scarcity and orphan bleeding disorders. Thus, general physicians may rarely encounter with these disorders in clinical practice. If we do not treat them satisfactorily, the hemorrhagic propensity of these diseases may be fatal. Rarity and distribution of affected patients in all countries in the world is one of problem in their clinical practice. In reality, the distribution of small number and various type of coagulation factor concentrates for rare bleeding disorders in a wide country is troublesome in practice for health provider systems.