Mesenchymal hamartoma of the chest wall is a rare benign tumor found in infants and young children. We present a male neonate with bilateral multifocal mesenchymal hamartoma of the chest wall since birth causing deformity of the chest wall and respiratory symptoms. Mesenchymal hamartoma is often unilateral and solitary, but multifocality could be expected in the absence of the malignancy. Mesenchymal hamartoma of the chest wall in infants should always be considered as the differential diagnosis of the chest wall masses in young children.