Volume 9, Issue 2 ( June 2017 2017)                   Iranian Journal of Blood and Cancer 2017, 9(2): 37-43 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kamali K, Taghavinasab R, Haghpanah S, Bordbar M, Kamalipour P. Brain MRI Findings in Children with Acute Lymphoblastic Leukemia. Iranian Journal of Blood and Cancer 2017; 9 (2) :37-43
URL: http://ijbc.ir/article-1-704-en.html
1- Assistant professor of Radiology, Radiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- Resident of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran
3- Assistant professor of Community Medicine, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- Associate professor of Pediatric Hematology-Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , bordbarm@sums.ac.ir
5- Medical student, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (5761 Views)

Background: Patients with leukemia are facing more complications in order to achieve longer survival. We aimed to evaluate the frequency of central nervous system abnormalities (CNS) on MRI of children with acute lymphoblastic leukemia (ALL).
Methods: Sixty-six children with diagnosis of ALL aged 2-18 years were recruited. Non-contrast sequences of brain MRI in addition to diffusion weighted imaging of brain were obtained with 1.5 T (Siemens medical system) scanners in their maintenance phase of treatment. The age of onset, type of leukemia, protocol of treatment, and elapsed time from diagnosis were recorded. Chi-square test was used to compare the groups and t-test was used to evaluate the effect of not normally distributed variables.
Results: 19 (28.8%) had abnormal CNS findings identified on MRI images including: nonspecific white matter high signal intensity in flair images with normal DWI, white matter ischemia proved on DWI, generalized brain atrophy, isolated mild enlargement of lateral ventricle and extracerebral complications including sinus thrombosis and sinusitis. Brain abnormalities were correlated with leukemia type, chemotherapy protocol and radiotherapy (P=0.006, 0.036, and 0.01, respectively).  
Conclusion: The wide spectrum of CNS abnormalities that were observed in children with ALL showed correlation with treatment methods and type of leukemia in this study. Combination of radiation therapy and chemotherapy increased CNS complications. Among extracerebral complications, dural sinus thrombosis proved by MRV was seen more frequently in T-cell leukemia patients treated with multiple high doses of the chemotherapy agent “L-asparaginase”. Since some neurological complications of leukemia are treatable, early diagnosis sounds essential.

Full-Text [PDF 681 kb]   (3757 Downloads)    
: Original Article | Subject: Pediatric Hematology & Oncology
Received: 2016/12/27 | Accepted: 2017/04/13 | Published: 2017/06/28

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 All Rights Reserved | Iranian Journal of Blood and Cancer

Designed & Developed by : Yektaweb