en Genetics Genetics پژوهشي Original Article <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Arial;"><span style="font-size:14px;">Background: Single nucleotide polymorphisms (SNPs) in the promoter region of miRNAs may disturb miRNAs processing, alter their expression, and ultimately affect an individual&rsquo;s susceptibility to cancer. We conducted a case-control study to evaluate the association of rs353293 G>A with the risk of thyroid cancer in the Iranian population.<br> Methods: 192 patients with thyroid cancer including (papillary, follicular, medullary, and undifferentiated) and 125 healthy subjects were enrolled in this case-control study. rs353293 G>A polymorphism in the promoter region of miR-143/145 were analyzed using polymerase chain reaction&ndash;restriction fragment length polymorphism (PCR-RFLP) to find the association of this SNP with thyroid cancer. Logistic regression analyses were conducted to evaluate adjusted odds ratios (ORs) for the potential confounding factors (age and sex), and 95% confidence intervals (95% CIs) between patients with thyroid cancer and controls.<br> Results: We found no association between rs353293 G>A polymorphism and thyroid cancer.&nbsp;<br> Conclusion: This study suggests that the functional polymorphism in rs353293 is not associated with development of thyroid cancer. Future investigations with larger sample size should be performed to confirm our observations.</span></span></span></p> Thyroid cancer, rs353293 G>A polymorphism, Mir 143, RFLP 6 11 http://ijbc.ir/browse.php?a_code=A-10-582-1&slc_lang=en&sid=1 Nima Montazeri-Najafabady montazerin@sums.ac.ir 10031947532846008985 10031947532846008985 No Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Hossein Dabbaghmanesh dabbaghm@sums.ac.ir 10031947532846008986 10031947532846008986 Yes Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Nazanin Chatrabnous chatrabnous2014@gmail.com 10031947532846008987 10031947532846008987 No Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Reza Arabnezhad mohammadarabnezhad1372@gmail.com 10031947532846008988 10031947532846008988 No Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Rajeeh Mohammadian Amiri 10031947532846008989 10031947532846008989 No Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran