en Infectious Diseases Infectious Diseases گزارش مورد Case report <div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Arial;"><b><span lang="EN-ID">Background:</span></b><span lang="EN-ID"> <span style="color:#212121">Infective endocarditis (IE) is a life-threatening systemic disease that mostly affects people with valvular heart disease, prosthetic valves, or intracardiac devices. Infective endocarditis is a dangerous cardiac involvement in thalassemia patients. Thus, a multidisciplinary approach is important to provide efficient and effective therapy.</span></span></span></span></span></div> <div style="margin-top: 3px; text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Arial;"><span style="color:#1f3763"><span style="font-weight:normal"><b><span lang="EN-ID"><span style="color:#212121">Case presentation:</span></span></b><span lang="EN-ID"><span style="color:#212121"> A 31-year-old man came to our tertiary referral hospital complaining of right-side paralysis of the body and slurred speech. Vital signs were normal. There were grade III/VI systolic murmurs from chest examination in midclavicular line intercostal space V sinistra. Head CT scan without contrast showed an embolic event.</span></span><span lang="EN-ID"> P</span><span lang="EN-ID"><span style="color:#212121">eripheral blood smear showed iron deficiency anemia. Further electrophoresis hemoglobin (Hb) examination showed HbE-pathy. </span></span><span lang="EN-ID">Echocardiography showed vegetations on the anterior and posterior mitral leaflet, leading to severe mitral regurgitation (MR). Blood culture examinations showed no bacterial growth. The patient was then diagnosed with severe MR due to possible IE, acute stroke infarction, and HbE thalassemia. The patient was treated with optimal medical therapy because he refused surgery. After six months of follow up, patients were found dead at his house</span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Arial;"><b><span lang="EN-ID"><span style="color:#212121">Conclusions:</span></span></b> <span lang="EN-ID"><span style="color:#212121">Thalassemia is a risk factor for infective endocarditis. Both are a dangerous combination, and early recognition should be made carefully to prevent worse outcome.</span></span></span></span></span></div> <span style="font-size: 10pt; white-space: pre-wrap;"><span style="tab-stops:1.0cm 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span courier="" new="" style="font-family:"><span new="" roman="" style="font-family:" times=""><span style="color:#212121"></span></span></span></span></span> Infective endocarditis, Negative Blood culture, Thalassemia, Stroke 111 115 http://ijbc.ir/browse.php?a_code=A-10-838-1&slc_lang=en&sid=1 Novia Kusumawardhani noviakusumawardhani@gmail.com 10031947532846008906 10031947532846008906 No Department of Cardiology and Vascular Medicine, Faculty of Medicine, Airlangga University – dr. Soetomo General Hospital, Surabaya, Indonesia Ivana Purnama Dewi 916ivana@gmail.com 10031947532846008907 10031947532846008907 Yes Department of Cardiology and Vascular Medicine, Faculty of Medicine, Airlangga University – dr. Soetomo General Hospital, Surabaya, Indonesia 2Faculty of Medicine Duta Wacana Christian University, Yogyakarta, Indonesia Louisa Fadjri Kusuma Wardhani louisafk@gmail.com 10031947532846008908 10031947532846008908 No Department of Cardiology and Vascular Medicine, Faculty of Medicine, Airlangga University – dr. Soetomo General Hospital, Surabaya, Indonesia Mohammad Budiarto raden-m-b@fk.unair.ac.id 10031947532846008909 10031947532846008909 No Department of Cardiology and Vascular Medicine, Faculty of Medicine, Airlangga University – dr. Soetomo General Hospital, Surabaya, Indonesia