en Adults Hematology & Oncology Adults Hematology & Oncology مقاله مروری Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Arial;"><span style="color:black">Nearly 50 % of newly diagnosed colorectal cancer, affect people over 70 years of age. Inclusion of older patients in clinical trials has been extremely rare. As a result, there is debate on how to manage these patients because it is still unclear how to balance the therapeutic advantages and toxicities. For patients who do not have comorbid conditions, with performance status <i>(P.S</i>.) 0&ndash;1, treatment guidelines are comparable to those for younger ones. Chemotherapy is an option for older patients; however, a full geriatric evaluation is recommended. Bevacizumab, an anti-vascular epithelial growth factor (<i>anti-VEGF</i>), combined with chemotherapy has become a standard of care in older patients. Anti-epidermal growth factor receptor <i>(anti-EGFR</i>) treatment is proposed both as monotherapy in the third-line or with chemotherapy in first or second line. Clinical trials that compared chemotherapy alone versus doublet chemotherapy plus anti-<i>EGFR</i> in older patients found that age is not an absolute contraindication for using anti-<i>EGFR</i> in first or second line. In fit older patients, anti-<i>EGFR</i> monotherapy in the first second or third line has demonstrated feasibility and antitumor efficacy. The major side effect is cutaneous rash which is easily managed. However, treatment in older patients should be carried out and be based on co-morbidities.<span style="font-family:"Times New Roman",serif"></span></span><br> &nbsp;</span></span></span></div> Metastatic colorectal cancer, Anti-EGFR, Chemotherapy, Toxicities 116 124 http://ijbc.ir/browse.php?a_code=A-10-906-1&slc_lang=en&sid=1 Alfredo Colombo alfredocolo63@gmail.com 10031947532846008815 10031947532846008815 Yes Oncology Unit C.D.C Macchiarella - Palermo-Italy Concetta Maria Porretto massimo69cp@libero.it 10031947532846008816 10031947532846008816 No Oncology Unit C.D.C Macchiarella - Palermo-Italy Ivan Fazio ivanfazio27@gmail.com 10031947532846008817 10031947532846008817 No Radiotherapy Unit CDC Macchiarella - Palermo- Italy Tommaso Sciacchitano tommaso.sciacchitano@tin.it 10031947532846008818 10031947532846008818 No Oncology Unit C.D.C Macchiarella - Palermo-Italy Antonella Mazzonello oncologia@casadicuramacchiarella.it 10031947532846008819 10031947532846008819 No Radiotherapy Unit CDC Macchiarella