en Methodology Methodology پژوهشي Original Article <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Arial;"><span style="font-size:14px;"><b>Background</b>: Biological resources, along with patient-related clinical data, are basically required for personalized medicine and translational research. In this regard, pediatric cancer biobanks have considerable significance due to their special challenges, which include the need for long-term sample collection (due to high diversity and rare tumors), the difficulty of working with children, as well as the limited volume of samples available in children.<br> <b>Methods</b>: After obtaining all necessary approvals (from the ethics committee, scientific board, and financial support), standard operating procedures (SOPs) were defined for all aspects of the biobank procedures, including equipping the lab, sample collection, processing, storage, as well as clinical data recording.<br> <b>Results</b>: Until July 2022, approximately 8,000 samples from 720 patients have been collected in the biobank. In summary, the samples in the biobank are classified into three categories: leukemia (40.7%), solid tumors (39.44%), and central nervous system tumors (15.56%). The unique activities of the biobank include the collection of various biological samples from patients and their parents, inter-university cooperation, the use of a vacuum system to preserve tissue, the launching of an online database for recording patients&#39; medical data, and the setting up of a bilingual website for announcements at the national and international levels.<br> <b>Conclusion</b>:&nbsp;Iranian Childhood Cancer Biobank (ICCBB) is the first pediatric biobank center in Iran that collects various samples and associated clinical data from patients with a wide range of childhood cancers. The ICCBB aims to advance clinical research in the field of pediatric cancer by providing both the required quantity and quality of biological samples.</span></span></span></p> Cancer, Biobank, Children, Pediatric cancer biobank 150 156 http://ijbc.ir/browse.php?a_code=A-10-918-1&slc_lang=en&sid=1 Peyman Eshghi peshghi64@gmail.com 10031947532846008917 10031947532846008917 No Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nasrin Dehghan-Nayeri nasrindehghan10@gmail.com 10031947532846008918 10031947532846008918 Yes Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Maryam Kazemi Aghdam m_kazemi_aghdam@yahoo.com 10031947532846008919 10031947532846008919 No Pediatric Pathology Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Yalda Nilipour yalnil@yahoo.com 10031947532846008920 10031947532846008920 No Pediatric Pathology Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohsen Rouzrokh mohsen_rouzrokh@yahoo.com 10031947532846008921 10031947532846008921 No Pediatric Surgery Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Zahra Badiei badieez@mums.ac.ir 10031947532846008922 10031947532846008922 No Department of Pediatric Hematology-Oncology, Dr Sheikh Pediatric Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran Hamid Farhangi farhangih@mums.ac.ir 10031947532846008923 10031947532846008923 No Department of Pediatric Hematology-Oncology, Dr Sheikh Pediatric Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran Mehran Noroozi mehranxnoroozi@gmail.com 10031947532846008924 10031947532846008924 No Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran Hasan Reza Mohammadi hrmohamadi@sbmu.ac.ir 10031947532846008925 10031947532846008925 No Department of Neurosurgery, Mofid children’s hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ehsan Moradi moradieh@sbmu.ac.ir 10031947532846008926 10031947532846008926 No Department of Neurosurgery, Mofid children’s hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Samin Alavi saminalavi@hotmail.com 10031947532846008927 10031947532846008927 No Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Leily Mohajerzadeh mohajerzadehl@yahoo.com 10031947532846008928 10031947532846008928 No Pediatric Surgery Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shahin Shamsian shahinshamsian@gmail.com 10031947532846008929 10031947532846008929 No Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ahmad Khaleghnejad Tabari khaleghnejad@gmail.com 10031947532846008930 10031947532846008930 No Pediatric Surgery Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Javad Ghoroubi jghoroubi@yahoo.com 10031947532846008931 10031947532846008931 No Pediatric Surgery Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nader Momtazmanesh nmomtazmanesh@yahoo.com 10031947532846008932 10031947532846008932 No Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mehdi Sarafi mehdicalls@yahoo.com 10031947532846008933 10031947532846008933 No Pediatric Surgery Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Reza shojaeian kalipoopo@gmail.com 10031947532846008934 10031947532846008934 No Department of General Surgery, Mashhad University of Medical Science, Mashhad, Iran Paria Dehghanian Dehghanianp2@mums.ac.ir 10031947532846008935 10031947532846008935 No Department of Pathology, Akbar children’s hospital, Mashhad, Iran Parastoo Molaei Tavana dr_p1984@yahoo.com 10031947532846008936 10031947532846008936 No Department of Pediatrics, Loghman Hakim hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran