en Pediatric Hematology & Oncology Pediatric Hematology & Oncology پژوهشي Original Article <p style="text-align: justify;"><span style="font-family:Arial;"><span style="font-size:14px;"><span style="line-height:2;"><span style="unicode-bidi:embed"><b>Background:</b> Acute lymphoblastic leukemia (ALL) causes uncontrolled cell proliferation and prevents normal cell differentiation at any stage of hematopoiesis. Therefore, timely diagnosis and treatment are very important. <span lang="EN">Complete blood count (CBC)</span> can be a simple, but valuable initial test to diagnose ALL. <span lang="EN">In this study, we investigated the diagnostic value of </span>hematological parameters, including <span lang="EN">Platelet to lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and</span> hemoglobin to Platelet ratio (HPR) indices in ALL.<span style="font-family:"Times New Roman",serif"></span></span><br> <span style="unicode-bidi:embed"><b>Methods:</b> In this study, 54 ALL patients (Mean ages: 5.29) and 58 healthy controls (Mean ages: 5.53) were evaluated. They were compared in terms of hematological parameters, including <span lang="EN">PLR, NLR, and</span> <span lang="EN">HPR;</span> cytogenetic and immunophenotypes were also analyzed.</span><br> <span style="unicode-bidi:embed"><b>Result:</b> In the analysis of hematological factors between the studied groups, all indices except lymphocytes showed a statistically significant relationship (P-Value ˂0.05). In terms of hematological factors, only WBC and ESR were statistically significant between the B-ALL and T-ALL groups (P-Value ˂0.05). The ROC curve was generated to select the appropriate cut-off values for NLR, PLR, and HPR based on analysis. NLR and PLR have cut-off values of 0.50 and 62.24, respectively; they are good biomarkers to distinguish ALL individuals from normal people. HPR value was significant between case and control groups, but it was not a suitable indicator for distinguishing patients from the control group.</span><br> <span style="unicode-bidi:embed"><b>Conclusion:</b> CBC is a simple and valuable test for early detection of ALL, and the new PLR and NLR markers are good hematologic markers for ALL diagnoses.</span></span></span></span></p> Acute lymphoblastic leukemia, Complete blood count, Diagnostic biomarker, NLR, PLR. 80 87 http://ijbc.ir/browse.php?a_code=A-10-976-1&slc_lang=en&sid=1 Bahareh Moghimian bahar.moghimian.74@gmail.com 10031947532846009447 10031947532846009447 No Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran Ahmad Jafari-joshaghan Jafarijoshaghan@gmail.com 10031947532846009448 10031947532846009448 No Department of Pathology, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran Hossein ayatollahi ayatollahih@mums.ac.ir 10031947532846009449 10031947532846009449 No Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh Shams shams8869@yahoo.com 10031947532846009450 10031947532846009450 No Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran Narjes Soltani narjessoltanei@gmail.com 10031947532846009451 10031947532846009451 No Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh Ahmadpour ahmadpourfatimaa@gmail.com 10031947532846009452 10031947532846009452 No Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Sepideh Shakeri se.shakeri@yahoo.com 10031947532846009453 10031947532846009453 No Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mohammadreza Javan javaneee@gmail.com 10031947532846009454 10031947532846009454 Yes Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran