en Adults Hematology & Oncology Adults Hematology & Oncology مقاله مروری Review Article <p style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Arial;"><b>Background:</b> Oncolytic virotherapy has emerged as a promising approach for the treatment of various cancers. This review article aims to provide an overview of Vesicular Stomatitis Virus (VSV) as an emerging anti-cancer therapy.<br> <b>Materials and Methods:</b> The article discusses the mechanism of action, preclinical and clinical studies, and challenges in the clinical translation of VSV. It also explores potential strategies to enhance the efficacy and safety of VSV-based oncolytic therapy, including combination therapies and genetic modifications<br> <b>Results:</b> The mechanisms underlying VSV-mediated anti-cancer activity, such as induction of apoptosis, activation of immune responses, and disruption of tumor vasculature, are explored. Additionally, known methods for the preparation of oncolytic VSV, including genetic modifications and combination therapies, are discussed to optimize its anti-cancer effects.<br> <b>Conclusion</b>: Strategies to enhance VSV efficacy and overcome safety challenges are examined, including the use of VSV in combination with other therapies, such as chemotherapy or immunotherapy, as well as the development of novel viral vectors and engineering approaches to improve tumor-specific targeting and minimize off-target effects. In conclusion, this review highlights the potential of VSV as a novel therapeutic strategy for cancer treatment. Harnessing the unique characteristics of VSV, combined with ongoing research and technological advancements, may pave the way for the development of effective and safe VSV-based therapies in the future.</span></span></span></p> Vesicular Stomatitis Virus (VSV), Cancer Treatment, Oncolytic, Virotherapy, Combination therapy, Oncogene targeting 117 127 http://ijbc.ir/browse.php?a_code=A-10-984-1&slc_lang=en&sid=1 Fatemeh Mousavinasab fatemeh.kmls@gmail.com 10031947532846009455 10031947532846009455 No Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA Elham Razani e_razani_mls@yahoo.com 10031947532846009456 10031947532846009456 Yes 1-Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran 2- 3- Scientific board, Colife Integrated Medical Labs, Tehran, Iran