en AI in Medicine مقاله مروری Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Arial;"><span style="unicode-bidi:embed">Celiac disease (CD) is an autoimmune digestive condition that is distinguished by inflammation of the small intestine as a result of gluten ingestion. Its worldwide prevalence is approximately 1%. Despite progress in understanding CD, challenges in pathogenesis, diagnosis, treatment, and management persist. Genetic and environmental factors, such as HLA and non-HLA genes, gluten, gut microbiota imbalance, and immune responses involving CD4+ T cells, influence CD. Diagnostic challenges arise due to diverse clinical presentations and overlap with other gastrointestinal disorders. Following a gluten-free diet (GFD) strictly is the primary treatment for CD, but this diet presents social, psychological, and financial hurdles. Artificial intelligence (AI) has emerged as a potent instrument in CD management. Techniques like machine learning (ML), deep learning (DL), natural language processing (NLP), and computer-aided algorithms have shown promise in CD diagnosis by improving microbiome analysis, disease prediction, interpretation of medical records and endoscopy images. AI-based decision-support systems can aid in diagnosis. AI-driven personalized nutrition and gluten contamination monitoring techniques offer potential improvements for treatment. Overall, AI has potential in addressing CD challenges and enhancing patient outcomes.</span></span></span></span><br> &nbsp;</div> Artificial intelligence, Celiac disease, Machine learning, Deep learning, Diagnosis 125 137 http://ijbc.ir/browse.php?a_code=A-10-1050-1&slc_lang=en&sid=1 Mohadeseh Mahmoudi Ghehsareh mohimahmoudi1998@gmail.com 100319475328460010023 100319475328460010023 No Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nastaran Asri nastaran.asri26@gmail.com 100319475328460010024 100319475328460010024 No Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sepehr Maleki sepehrmaleki88@gmail.com 100319475328460010025 100319475328460010025 No Department of Computer Science, University of Tabriz, Tabriz, Iran Mostafa Rezaei-Tavirani tavirany@yahoo.com 100319475328460010026 100319475328460010026 No Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Somayeh Jahani-Sherafat jahani_somayeh@yahoo.com 100319475328460010027 100319475328460010027 No Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Rostami-Nejad m.rostamii@gmail.com 100319475328460010028 100319475328460010028 Yes Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran