en Adults Hematology & Oncology Adults Hematology & Oncology پژوهشي Original Article <span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Arial;"><span style="color:black"><b>Introduction: </b>The role of Plasma-Derived Medicinal Products (PDMPs) in managing life-threatening diseases is remarkable. Human plasma as a raw material for PDMPs is obtained from volunteers through apheresis or whole blood collection. The global PDMPs market in 2021 shows an average annual growth rate of 7.4% since 1996 <span dir="RTL" lang="AR-SA">which</span> is higher than the average annual pharmaceutical market growth rate. In line with WHO policies, Iran has improved its national voluntary non-remunerated donors (VNRD) program to supply the local PDMPs market. This study shows the 10-year Iran PDMPs market evolution to assess its self-sufficiency<span dir="RTL" lang="FA">.</span></span><br> <span style="color:black"><b>Method: </b>We conducted a cross-sectional study from 2012 to 2021 to assess the self-sufficiency rate of Iran&rsquo;s plasma industry for PDMPs including Albumin, Immune globulins, and Antihemophilic Factors. In addition, we show the gap between market supply and demand to lighten the self-sufficiency future.</span><br> <span style="color:black"><b>Result: </b>The annual growth rate of total collected plasma was 18.9% over 10 years in Iran from 2012 to 2021. Although the consumption rate of intravenous Immune globulins has increased from 777 kg to 2,108 Kg, due to a significant increase in local plasma production, its self-sufficiency rate increased from 53% to 93%.&nbsp; Similarly, the demand rate for Albumin grew from 21% in 2012 to 90% in 2021.</span><br> <span style="color:black"><b>Discussion: </b>Although local plasma production in Iran significantly provided plasma self-sufficiency as a raw material, local market demand for PDMPs is mainly supplied through contract fractionation with European fractionators.&nbsp; Access to complete self-sufficiency in Iran needs increasing plasma production, as well as developing major local plasma fractionators.</span></span></span></span> Plasma-Derived Medicinal Products, Fractionation, Yield, Self-Sufficiency, Immune Globulin, Albumin 59 66 http://ijbc.ir/browse.php?a_code=A-10-1059-1&slc_lang=en&sid=1 Zahra Ghasemi matinaghasemi@gmail.com 100319475328460010475 100319475328460010475 No Ph.D. Student of Pharmacoeconomics and Pharma Management, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hassan Abolghasemi h.abolghasemi.ha@gmail.com 100319475328460010476 100319475328460010476 No Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fatemeh Babaei ph.fatemeh@yahoo.com 100319475328460010477 100319475328460010477 No Department of Pharmacoeconomics and Pharma Management, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Abdol Majid Cheraghali majidcheraghali@gmail.com 100319475328460010478 100319475328460010478 No Professor of Pharmacology, Board member of Iranian Academy of Medical Sciences, Iranian Academy of Medical Sciences, Tehran, Iran Nazila Yousefi n.yousefi@sbmu.ac.ir 100319475328460010479 100319475328460010479 Yes Department of Pharmacoeconomics and Pharma Management, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran