en Pediatric Hematology & Oncology Pediatric Hematology & Oncology پژوهشي Original Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Arial;">The health-related quality of life and management of patients with thalassemia has significantly improved in recent years due to standard treatments and safe blood transfusions with effective chelation therapy to reduce iron overload. Transfusion-dependent thalassemia is associated with numerous skeletal abnormalities, including osteoporosis, which is a significant cause of morbidity in these patients. Osteoporosis is characterized by low bone mass and an increased risk of fractures, particularly in the lumbar spine and in patients with extramedullary hematopoiesis. It remains a significant problem in adult transfusion-dependent thalassemia, particularly in patients under chelation therapy. A fracture history is significantly associated with lower Dual-Energy X-ray Absorptiometry (DEXA) T/Z scores, which decrease with age. Improved management and modern treatments for transfusion-dependent thalassemia patients with osteoporosis should be prioritized to prevent bone fractures and improve quality of life in older age.</span></span></span></div> Osteoporosis, Transfusion, Thalassemia, Bone mineral density, Fracture. 53 58 http://ijbc.ir/browse.php?a_code=A-10-41-6&slc_lang=en&sid=1 Mojtaba Malek malekmoj@yahoo.com 100319475328460010394 100319475328460010394 No Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran Mohammad E. Khamseh m.e.khamseh@gmail.com 100319475328460010395 100319475328460010395 No Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran Pooya Faranoush pooya1375@yahoo.com 100319475328460010396 100319475328460010396 No Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran Nahid Hashemi-madani nahid.hashemimadani@gmail.com 100319475328460010397 100319475328460010397 No Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran Neda Rahimian rahimian.n@iums.ac.ir 100319475328460010398 100319475328460010398 No Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran Fariba Ghassemi fariba.ghasemi@yahoo.com 100319475328460010399 100319475328460010399 No Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran Mohammad Reza Foroughi-Gilvaee emad.foroughi95@gmail.com 100319475328460010400 100319475328460010400 No Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran Negin Sadighnia negin_sadighnia@yahoo.com 100319475328460010401 100319475328460010401 No Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran Ali Elahinia elahinia.ali75@gmail.com 100319475328460010402 100319475328460010402 No Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran Mohammad Reza Rezvany rezvani.mr@iums.ac.ir 100319475328460010403 100319475328460010403 No Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran Dorsa Fallah Azad dorsafallah99@gmail.com 100319475328460010404 100319475328460010404 No Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran Mohammad Faranoush faranoush47@gmail.com 100319475328460010405 100319475328460010405 Yes Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran